Adenovirus Gene Delivery

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Adenovirus: The First Effective In Vivo Gene Delivery Vector

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900005/
    Jan 01, 2014 · Introduction. T he adenovirus, an 80–100 nm, nonenveloped, icosahedral capsid, double-stranded DNA virus, is a well-known cause of respiratory tract infections (Ginsberg, 1984).Adenovirus infection in humans usually is mild, but in immunocompromised individuals, it can be life threatening. The adenovirus was first isolated from human adenoids in 1953.Author: Ronald G. Crystal

Comparison of Gene Delivery to the Kidney by Adenovirus ...

    https://www.liebertpub.com/doi/10.1089/hum.2019.127
    Dec 16, 2019 · Comparison of Gene Delivery to the Kidney by Adenovirus, Adeno-Associated Virus, and Lentiviral Vectors After Intravenous and Direct Kidney Injections. Jeffrey D. Rubin, Tien V. Nguyen, Kari L. Allen, Katayoun Ayasoufi, and ; Michael A. BarryAuthor: Jeffrey D. Rubin, Tien V. Nguyen, Kari L. Allen, Katayoun Ayasoufi, Michael A. Barry

Adenovirus-mediated gene delivery: Potential applications ...

    https://www.sciencedirect.com/science/article/pii/S2352304217300272
    Among all currently available viral vectors, adenovirus is the most efficient gene delivery system in a broad range of cell and tissue types. The applications of adenoviral vectors in gene delivery have greatly increased in number and efficiency since their initial development.Author: Cody S. Lee, Elliot S. Bishop, Ruyi Zhang, Ruyi Zhang, Xinyi Yu, Xinyi Yu, Evan M. Farina, Shujuan Y...

Adenovirus Packaging Services, Custom Adenovirus Vigene

    https://www.vigenebio.com/adenovirus-packaging/
    Adenovirus is a popular choice for gene delivery applications primarily because of its large packaging capacity, high transgene expression, and ability to infect most cell types. Note: Vigene offers only recombinant adenovirus products and services. We do not work with or sell wild-type adenovirus.

Viral and nonviral delivery systems for gene delivery

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507026/
    Jul 06, 2012 · INTRODUCTION. Basically gene therapy is an intracellular delivery of genomic materials (transgene) into specific cells to generate a therapeutic effect by correcting an existing abnormality or providing the cells with a new function.[] Different types of gene delivery systems may be applied in gene therapy to restore a specific gene function or turning off a special gene(s).

Adenoviruses as Gene-Delivery Vehicles NEJM

    https://www.nejm.org/doi/full/10.1056/NEJM199605023341809
    For gene therapy to realize its clinical potential, there must be efficient and safe strategies of delivering therapeutic genes to somatic cells in vivo. Perhaps this problem simply represents a sp...Author: James M. Wilson

Role of αv Integrins in Adenovirus Cell Entry and Gene ...

    https://mmbr.asm.org/content/63/3/725
    Sep 01, 1999 · Ad-mediated gene delivery is influenced not only by α v integrin expression but also by the presence of the fiber receptor, CAR. For example, a recent study of Ad gene delivery to a panel of human glioma cell lines indicated that Ad infection was dependent upon the level of CAR expression rather than on the presence of α v integrins .Author: Glen R. Nemerow, Phoebe L. Stewart

Adenovirus: The First Effective In Vivo Gene Delivery ...

    https://www.liebertpub.com/doi/full/10.1089/hum.2013.2527
    Jan 20, 2014 · Adenovirus-mediated gene delivery: Potential applications for gene and cell-based therapies in the new era of personalized medicine. Genes & Diseases, Vol. 4, No. 2. Polymeric Vectors for Strategic Delivery of Nucleic Acids. Nano LIFE, Vol. 07, No. 02.Author: G CrystalRonald

Adenovirus miRNAs Products Vigene Biosciences

    https://www.vigenebio.com/products/adenovirus-products/adenovirus-mirnas
    Recombinant viruses are excellent tools for miRNA delivery in both dividing and non-dividing cells. Adenovirus miRNAs in particular are a great choice if you need high transduction efficiency and transient expression. If you are unsure which virus to use, we recommend reading our Viral Delivery Guide.Brand: Vigenebio

Adenovirus-mediated gene delivery into mouse ...

    https://www.pnas.org/content/104/8/2596
    Feb 20, 2007 · The purpose of this study is to examine the feasibility of adenovirus-mediated gene delivery to spermatogonial stem cells. We hypothesized that adenovirus infection did not occur in previous studies because of inefficient exposure of germ cells (or stem cells) to adenovirus and/or low sensitivity of the detection methods.Author: Masanori Takehashi, Mito Kanatsu-Shinohara, Kimiko Inoue, Narumi Ogonuki, Hiromi Miki, Shinya Toyoku...

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