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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900005/
Jan 01, 2014 · Introduction. T he adenovirus, an 80–100 nm, nonenveloped, icosahedral capsid, double-stranded DNA virus, is a well-known cause of respiratory tract infections (Ginsberg, 1984).Adenovirus infection in humans usually is mild, but in immunocompromised individuals, it can be life threatening. The adenovirus was first isolated from human adenoids in 1953.Author: Ronald G. Crystal
https://www.liebertpub.com/doi/full/10.1089/hum.2013.2527
Jan 20, 2014 · The first example of effective in vivo gene transfer using an adenovirus vector. ... Affinity maturation of an anti-V antigen IgG expressed in situ through adenovirus gene delivery confers enhanced protection against Yersinia pestis challenge. Gene Ther. 17, 913–921.Author: G CrystalRonald
https://www.sciencedirect.com/science/article/pii/S2352304217300272
Adenovirus-mediated gene delivery: Potential applications for gene and cell-based therapies in the new era of personalized medicine. ... It is wildly recognized that poor gene delivery is the limiting factor for most in vivo gene therapies. There has been a long-lasting interest in using viral vectors, especially adenoviral vectors, to deliver ...Author: Cody S. Lee, Elliot S. Bishop, Ruyi Zhang, Ruyi Zhang, Xinyi Yu, Xinyi Yu, Evan M. Farina, Shujuan Y...
https://www.liebertpub.com/doi/10.1089/hum.2019.127
Dec 16, 2019 · Comparison of Gene Delivery to the Kidney by Adenovirus, Adeno-Associated Virus, and Lentiviral Vectors After Intravenous and Direct Kidney Injections. Jeffrey D. Rubin, ... Falck-Pedersen E, et al. Innate immune mechanisms dominate elimination of adenoviral vectors following in vivo administration. Hum Gene Ther 1997;8:37–44.Author: Jeffrey D. Rubin, Tien V. Nguyen, Kari L. Allen, Katayoun Ayasoufi, Michael A. Barry
https://journals.physiology.org/doi/full/10.1152/ajpheart.00323.2006
In vivo gene delivery of HSP70i by adenovirus and adeno-associated virus preserves contractile function in mouse heart following ischemia-reperfusion. Darrell D. Belke, Bernd Gloss, John M. Hollander, Eric A. Swanson, Hervé Duplain, and ; Wolfgang H. Dillmann
https://www.nejm.org/doi/full/10.1056/NEJM199605023341809
For gene therapy to realize its clinical potential, there must be efficient and safe strategies of delivering therapeutic genes to somatic cells in vivo. Perhaps this problem simply represents a sp...Author: James M. Wilson
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