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https://www.sciencedirect.com/science/article/pii/S2352304217300272
Adenovirus-mediated gene delivery in regenerative medicine. The use of adenoviral vectors for genetic engineering has opened new areas of investigation in most areas of medicine. From basic science laboratories to multi-center clinical trials, this promising field …Author: Cody S. Lee, Elliot S. Bishop, Ruyi Zhang, Ruyi Zhang, Xinyi Yu, Xinyi Yu, Evan M. Farina, Shujuan Y...
https://www.pnas.org/content/104/8/2596
Feb 20, 2007 · The purpose of this study is to examine the feasibility of adenovirus-mediated gene delivery to spermatogonial stem cells. We hypothesized that adenovirus infection did not occur in previous studies because of inefficient exposure of germ cells (or stem cells) to adenovirus and/or low sensitivity of the detection methods.Author: Masanori Takehashi, Mito Kanatsu-Shinohara, Kimiko Inoue, Narumi Ogonuki, Hiromi Miki, Shinya Toyoku...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2683146/
The results demonstrate that adenovirus-mediated, hepatic methylmalonyl-CoA mutase expression can rescue Mut −/− pups from neonatal mortality and provide proof-of-principle evidence for the efficacy of liver-directed gene delivery in methylmalonic acidemia.Author: Randy J. Chandler, Charles P. Venditti
https://www.sciencedirect.com/science/article/pii/S1742706119305471
Exploring the functions of polymers in adenovirus-mediated gene delivery: Evading immune response and redirecting tropism. Author links open overlay panel Yanping Sun a b c Xiaoqian Lv a Pingtian Ding d Long Wang b e Yongjun Sun a c Shuo Li b Huimin Zhang b Zibin Gao a b c. Show more.Author: Yanping Sun, Xiaoqian Lv, Pingtian Ding, Long Wang, Long Wang, Yongjun Sun, Shuo Li, Huimin Zhang, Z...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC192116/
T cells are primary targets in numerous gene therapy protocols. However, the use of subgroup C adenovirus serotype 2 or 5 (Ad2 or Ad5) as a vector to transduce T cells is limited by its poor transduction efficiency for these cells. In this report we show ...Author: T J Wickham, G M Lee, J A Titus, G Sconocchia, T Bakács, I Kovesdi, D M Segal
https://www.liebertpub.com/doi/10.1089/hum.2019.127
Dec 16, 2019 · There are many kidney diseases that might be addressed by gene therapy. However, gene delivery to kidney cells is inefficient. This is due, in part, to the fact that the kidney excludes molecules above 50 kDa and that most gene delivery vectors are megaDaltons in mass.Author: Jeffrey D. Rubin, Tien V. Nguyen, Kari L. Allen, Katayoun Ayasoufi, Michael A. Barry
https://www.pnas.org/content/pnas/104/8/2596.full.pdf
Adenovirus-mediated gene delivery into mouse spermatogonial stem cells Masanori Takehashi*, Mito Kanatsu-Shinohara*†, Kimiko Inoue‡, Narumi Ogonuki‡, Hiromi Miki‡, Shinya Toyokuni§, Atsuo Ogura‡, and Takashi Shinohara*¶ *Department of Molecular Genetics, †Horizontal Medical Research Organization, and §Department of Pathology and Biology of Diseases, Graduate SchoolAuthor: Masanori Takehashi, Mito Kanatsu-Shinohara, Kimiko Inoue, Narumi Ogonuki, Hiromi Miki, Shinya Toyoku...
https://link.springer.com/protocol/10.1385/1-59259-650-9:3
Abstract. Adenoviruses, which were first isolated in the 1950s, have been developed as gene-delivery vehicles, or vectors, since the early 1980s ().The adenoviruses constitute the Adenoviridae family, which is divided into two genera: the Aviadenovirus genus infects only birds, whereas the Mastadenovirus genus contains viruses that infect a range of mammalian species.Author: Joanne T. Douglas
https://www.researchgate.net/publication/225264340_Adenovirus-Mediated_Gene_Delivery
Replication-defective vectors based on human adenovirus serotypes 2 and 5 (Ad2 and Ad5) possess a number of attributes which favor their use as gene delivery vehicles in gene therapy applications.
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