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https://www.researchgate.net/publication/12467817_Adeno-Associated_Viral_Vectors_as_a_Gene_Delivery_Vehicles_Review
Recombinant adeno-associated virus (rAAV) is a potent gene delivery vehicle capable of efficient transduction of transgenic DNA into cells. rAAV stays mainly as an episome in nondividing cells ...
https://link.springer.com/protocol/10.1007%2F978-1-0716-0175-4_7
Initially discovered as a contaminant of adenovirus preparations, adeno-associated virus (AAV) has proved one of the most promising viral vectors for human gene therapy. The safety profile of AAV has been well-characterized in vivo studies, and the first gene therapy for patients with vision loss caused by Leber congenital amaurosis or ...
https://www.nature.com/articles/s41573-019-0012-9
Adeno-associated virus (AAV) vectors are the leading platform for gene delivery for the treatment of a variety of human diseases. Recent advances in developing clinically desirable AAV capsids ...
https://www.sciencedirect.com/science/article/abs/pii/S0163725898000205
These properties make viruses attractive gene-delivery vehicles, or vectors, for gene therapy. Several types of viruses, including retrovirus, adenovirus, adeno-associated virus (AAV), and herpes simplex virus, have been modified in the laboratory for use in gene therapy applications.
https://www.tandfonline.com/doi/abs/10.1080/14712598.2020.1725469?needAccess=true
Introduction: The development of adeno-associated virus (AAV) vectors as safe vehicles for in vivo delivery of therapeutic genes has been a major milestone in the advancement of gene therapy, enabl...
https://www.creative-biolabs.com/gene-therapy/viral-vector-design-and-construction.htm
Adeno-associated virus vector. The adeno-associated virus (AAV) is a small virus that displays low immunogenicity and apparent lack of pathogenicity. Creative Biolabs provides AAV vectors characterized by molecular engineering and directed evolution to generate powerful delivery vectors with enhanced properties for the treatment of human ...
https://www.sciencedirect.com/science/article/pii/S0024320520302988
Improving the efficiency and clinical safety of recombinant bacterial and viral vectors could help in accepting these vaccines for therapeutic use. Producing a suitable vaccine delivery vehicle is a challenge which needs to be overcome for the gene therapy to be accepted and get regulatory approval for treating breast cancers.
http://www.cchem.berkeley.edu/schaffer/2006%20Publications/Maheshri_AAVevo_NBT_06.pdf
Directed evolution of adeno-associated virus yields enhanced gene delivery vectors Narendra Maheshri1, James T Koerber1, Brian K Kaspar2 & David V Schaffer1 Adeno-associated viral vectors are highly safe and efficient gene delivery vehicles.
https://www.thermofisher.com/us/en/home/references/gibco-cell-culture-basics/transfection-basics/gene-delivery-technologies/viral-delivery/viral-vectors.html
Other viral vector systems that can be used for overexpression of proteins include vectors based on baculovirus, vaccinia virus, and herpes simplex virus.While baculoviruses normally infect insect cells, recombinant baculoviruses can serve as gene-transfer vehicles for transient expression of recombinant proteins in a wide range of mammalian cell types.
https://en.wikipedia.org/wiki/Adeno-associated_virus
History. The adeno-associated virus (AAV), previously thought to be a contaminant in adenovirus preparations, was first identified as a dependoparvovirus in the 1960s in the laboratories of Bob Atchison at Pittsburgh and Wallace Rowe at NIH.Serological studies in humans subsequently indicated that, despite being present in people infected by helper viruses such as adenovirus or herpes virus ...
http://www.genetherapynet.com/viral-vectors.html
Viral vectors have natural host cell populations that they infect most efficiently. Retroviruses have limited natural host cell ranges, and although adenovirus and adeno-associated virus are able to infect a relatively broader range of cells efficiently, some cell types are refractory to infection by these viruses as well. Attachment to and entry into a susceptible cell is mediated by the ...
https://www.nature.com/articles/s41576-019-0205-4
Adeno-associated virus (AAV) vector-mediated gene delivery was recently approved for the treatment of inherited blindness and spinal muscular atrophy, and long-term therapeutic effects have been ...
https://www.mdpi.com/1999-4923/12/4/335
3 days ago · As an alternative to eye drops and ocular injections for gene therapy, the aim of this work was to design for the first time hydrogel contact lenses that can act as platforms for the controlled delivery of viral vectors (recombinant adeno-associated virus, rAAV) to the eye in an effective way with improved patient compliance.
http://www.cchem.berkeley.edu/schaffer/2006%20Publications/Koerber_NatProtocols_06.pdf
Construction of diverse adeno-associated viral libraries for directed evolution of enhanced gene delivery vehicles James T Koerber1, Narendra Maheshri2, Brian K Kaspar3 & David V Schaffer1 1Department of Chemical Engineering and the Helen Wills Neuroscience Institute, University of California, Berkeley, California 94720-1462, USA. 2Department of Chemical Engineering, …
https://www.grandviewresearch.com/industry-analysis/viral-vector-manufacturing-market
The global viral vectors & plasmid DNA manufacturing market size was estimated at USD 368.3 million in 2019 and is projected to expand at a CAGR of 14.52% during the forecast period. Advent of advanced therapies including gene therapy that employs the use of various viral and non-viral vectors has paved a way for the treatment of several heritable and acquired diseases that previously lacked ...
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