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https://link.springer.com/protocol/10.1007/978-1-61779-370-7_9
Sep 27, 2011 · Su, H., Lu, R., and Kan, Y. W. (2000) Adeno-associated viral vector-mediated vascular endothelial growth factor gene transfer induces neovascular formation in ischemic heart, Proc Natl Acad Sci U S A 97, 13801–13806. PubMed CrossRef Google ScholarAuthor: Lawrence T. Bish, H. Lee Sweeney, Oliver J. Müller, Raffi Bekeredjian
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1365046/
Quantification of vector genome copy numbers in heart and tibialis anterior muscle ... To determine whether uniform dystrophin expression could be obtained after intravascular vector delivery, ... et al. Stable restoration of the sarcoglycan complex in dystrophic muscle perfused with histamine and a recombinant adeno-associated viral vector.Author: Paul Gregorevic, Michael J Blankinship, James M Allen, Robert W Crawford, Leonard Meuse, Daniel G Mi...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655838/
Sep 01, 2017 · Use of Adeno-Associated Virus Vector for Cardiac Gene Delivery in Large-Animal Surgical Models of Heart Failure. ... The two basic, primarily used methods of AAV delivery into the heart are intramyocardial injection and intravascular infusion (Table 1). ... selecting the mode and dose of viral delivery. They have laid the foundation for future ...
https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.118.313811
Adeno-associated virus (AAV) is widely used as a gene transfer vector in biomedical and gene therapy studies. 5 AAV serotype 9 (AAV9) can efficiently transduce cardiac myocytes, among other cell and tissue types. 6 AAV9 can package sequences up to 4.7 kb that may include a tissue-specific promoter that drives gene expression in the transduced ...Author: Li Ni, Larry Scott, Hannah M Campbell, Xiaolu Pan, Katherina M Alsina, Julia O Reynolds, Leonne E Ph...
https://www.sciencedirect.com/topics/neuroscience/adeno-associated-virus
Adeno-associated viruses enter the cell through integrins, FGF receptor 1 and heparin sulfate proteoglycan receptors. They can travel across the endothelial barrier and reach the cardiomyocytes, which allows myocardial delivery of the adeno-associated virus vector through intracoronary arterial infusion (Lyon et al., 2008). One disadvantage of ...
https://www.sciencedirect.com/science/article/pii/S1443950618301203
V.R. Arruda, W. XiaoIt’s all about the clothing: capsid domination in the adeno-associated viral vector world. ... D.M. KayeAugmentation of left ventricular mechanics by recirculation-mediated AAV2/1-SERCA2a gene delivery in experimental heart failure. Eur J Heart Fail, 13 (2011), pp. 247-253.Author: Sebastian Bass-Stringer, Bianca C. Bernardo, Bianca C. Bernardo, Clive N. May, Colleen J. Thomas, Co...
https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.114.302331
The use of vectors based on the small parvovirus adeno-associated virus has gained significant momentum during the past decade. Their high efficiency of transduction of postmitotic tissues in vivo, such as heart, brain, and retina, renders these vectors extremely attractive for several gene therapy applications affecting these organs.Author: Serena Zacchigna, Lorena Zentilin, Mauro Giacca
https://www.addgene.org/guides/aav/
University of South Carolina's Viral Vector Core AAV Overview; Publications Viral serotypes and pseudotyping/gene therapy: Designer gene delivery vectors: molecular engineering and evolution of adeno-associated viral vectors for enhanced gene transfer. Kwon I, Schaffer DV. Pharm Res. 2008 Mar;25(3):489-99. PubMed. Adeno-associated virus ...
https://www.nature.com/articles/s41434-019-0097-0
Aug 29, 2019 · Differences between mouse and human hearts pose a significant limitation to the value of small animal models when predicting vector behavior following recombinant adeno-associated viral …Author: Melad Farraha, Michael A. Barry, Juntang Lu, Jim Pouliopoulos, Thi Y. L. Le, Sindhu Igoor, Renuka Ra...
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