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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1559924/
Jun 25, 2006 · Delivery of chemically synthesized siRNA In this approach, reconstituted viral envelopes derived from influenza virus are used to encapsulate and deliver siRNAs. The reconstituted membrane vesicles contain the influenza virus spike protein hemagglutinin and additionally added cationic lipids.Author: Sabrina Oliveira, Gert Storm, Raymond M. Schiffelers
https://www.thermofisher.com/us/en/home/life-science/rnai/delivering-rnai-to-cells-transfection-and-viral-delivery.html.html
Delivering RNAi to Cells - Transfection and Viral Delivery. The two common approaches for RNAi delivery are lipid-mediated transfection and viral-mediated transduction. Determining which one of these approaches to use depends on the cell type being studied and whether transient or stable knockdown is desired (Tables 1 & 2).
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2692493/
Jun 01, 2009 · Non-viral vectors for siRNA delivery. Of primary consideration in deciding on a drug delivery system for siRNA is whether the intended disease target lends itself to systemic or local administration. In the case of delivery of DNA encoding for the short hairpin RNA (shRNA) by non-viral delivery systems, nuclear translocation of the DNA is often ...Author: Kun Gao, Leaf Huang
https://www.alliedacademies.org/articles/rethinking-delivery-viral-vectors-and-rna-interference-7646.html
These shRNAs are processed by the cellular machinery into siRNAs, which then knockdown the target gene. This strategy not only allows prolonged silencing, as the shRNAs are continuously produced, it also opens up the possibility of using viral vectors for the delivery of double-stranded RNA molecules.Author: Jens Kurreck
https://www.jci.org/articles/view/33494
The siRNA delivery (or transfection) reagent complexes are often specifically referred to as lipoplexes, dendriplexes, and polyplexes, depending on whether the vector used is a cationic lipid, dendrimer, or polymer, respectively.
https://www.intechopen.com/books/rna-interference/non-viral-sirna-and-shrna-delivery-systems-in-cancer-therapy
Viral delivery systems have serious problems. Therefore, non-viral systems are more attractable than viral systems for siRNAs. Cationic lipids, liposomes, and polymers such as chitosan, PEI, PLL, and PLGA are used as non-viral siRNA delivery system. However, more suitable carriers are needed for siRNA delivery systems.Author: Emine Şalva, Ceyda Ekentok, Suna Özbaş Turan, Jülide Akbuğa
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