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https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/capsid
The most widely used viral capsids include the protein cage of the cowpea mosaic virus (CPMV), cowpea chlorotic mottle virus (CCMV), and MS2 bacteriophage. The application of viral capsids in targeted drug delivery and diagnostic imaging has been demonstrated over the past few decades.
https://www.sciencedirect.com/science/article/pii/S0169409X12000087
Apart from simple disassembly/reassembly of the viral capsid, drug cargo can also be loaded through covalent attachment of drugs or their analogs to certain reactive moieties on the capsid proteins. Moreover, residues can also be site-specifically engineered into the capsid protein to …Author: Y. Ma, Y. Ma, R.J.M. Nolte, Jeroen Johannes Lambertus Maria Cornelissen
https://escholarship.org/uc/item/0nk055f9
A targeted drug delivery vehicle based on the bacteriophage MS2 viral capsid was constructed using site-selective bioconjugation reactions. A palladium-catalyzed tyrosine allylation reaction was evaluated for interior modification of intact MS2 capsids with water-insoluble drug molecules.Author: Wesley Wu
https://www.sciencedaily.com/releases/2020/03/200309165241.htm
Mar 09, 2020 · "These viral capsids can be used as nano-containers for transporting drugs as cargo to specific targets. What makes them highly promising for drug delivery and gene delivery …
https://onlinelibrary.wiley.com/doi/abs/10.1002/mabi.201300401
Catechol ligands are chemically attached to the interior surface of P22 viral capsid for subsequent encapsulation of an anticancer drug, bortezomib (BTZ), through boronic acid‐diol complexation. For targeted delivery, hepatocellular carcinoma (HCC)‐targeting peptide (SP94, SFSIIHTPILPL) is synthesized and chemically conjugated to the exterior surface of the P22 viral capsid nanocomposites.Author: Junseon Min, Hyojin Moon, Hyun Ji Yang, Hyun‐Hee Shin, Sung You Hong, Sebyung Kang
https://www.nature.com/articles/s41467-018-03783-y
Apr 11, 2018 · As MS2 VLPs are used primarily as scaffolding in targeted drug delivery, selections based on infectivity are less relevant in this context.Author: Emily C. Hartman, Christopher M. Jakobson, Christopher M. Jakobson, Andrew H. Favor, Marco J. Lobba,...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2919582/
The capsid protein assembles in E. coli after recombinant expression, 16 yielding non-infectious genome-free particles with adjustable amino acid composition. The capsid structure is inherently monodisperse, an important advantage for the controlled biodistribution of drug delivery vehicles.Author: Wesley Wu, Sonny C. Hsiao, Zachary M. Carrico, Matthew B. Francis
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5689521/
Jan 19, 2017 · An alternate type of drug delivery NP that is showing promise is the VLP. 20 VLPs are self‐assembled, homogeneous NPs derived from the coat proteins of viral capsids. They typically lack their natural genome and are therefore noninfectious.Author: Marcus J. Rohovie, Maya Nagasawa, James R. Swartz
https://pubs.acs.org/doi/10.1021/bc070006e
With the development of covalent modification strategies for viral capsids comes the ability to convert them into modular carrier systems for drug molecules and imaging agents. With this overall goal in mind, we have used two orthogonal modification strategies to decorate the exterior surface of genome-free MS2 capsids with PEG chains, while installing 50−70 copies of a fluorescent dye inside as a drug cargo …Author: Ernest W. Kovacs, Jacob M. Hooker, Dante W. Romanini, Patrick G. Holder, Katherine E. Berry, Matthew...
https://www.nature.com/articles/s41573-019-0012-9
Feb 01, 2019 · Adeno-associated virus (AAV) vectors are the leading platform for gene delivery for the treatment of a variety of human diseases. Recent advances in developing clinically desirable AAV capsids, optimizing genome designs and harnessing revolutionary biotechnologies have contributed substantially to the growth of the gene therapy field.Author: Dan Wang, Phillip W. L. Tai, Guangping Gao
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