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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507026/
Jul 06, 2012 · Although numerous viral and nonviral gene delivery systems have been developed in the last 3 decades, no delivery system has been designed that can be applied in gene therapy of all kinds of cell types in vitro and in vivo with no limitation and side effects.
https://www.sciencedirect.com/science/article/pii/S0142961218302862
Nevertheless, with the rapid development of various synthetic vectors, non-viral vectors are very likely to provide unique advantages over viral vectors in these fields. Here, we review recent advances of non-viral vectors for CRISPR/Cas9 delivery in vivo and focus on those non-viral delivery systems applied for CRISPR/Cas9-based gene therapy.Author: Ling Li, Ling Li, Shuo Hu, Xiaoyuan Chen
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417261/
Mar 12, 2019 · In this article, the recent advances in the development of gene delivery systems have reviewed, including the progress of viral gene delivery systems and non-viral gene delivery systems. The viral gene delivery systems have discussed for the viral vectors based on DNA, RNA, and oncolytic viral vectors, respectively.Author: YK Sung, SW Kim
https://www.intechopen.com/books/recent-advances-in-novel-drug-carrier-systems/gene-delivery-systems-recent-progress-in-viral-and-non-viral-therapy
Current gene delivery systems are divided into three categories: viral-based, non-viral based, and combined hybrid systems. Viral gene delivery systems consist of viruses that are modified to be replication-deficient which can deliver genes to the target cells to provide expression.Author: Erdal Cevher, Ali Demir Sezer, Emre Şefik Çağlar
https://www.intechopen.com/books/gene-therapy-tools-and-potential-applications/non-viral-delivery-systems-in-gene-therapy
Gene delivery systems include viral vectors and non-viral vectors. Viral vectors are the most effective, but their application is limited by their immunogenicity, oncogenicity and the small size of the DNA they can transport. Non-viral vectors are safer, of low cost, more reproducible and do not present DNA size limit.Author: Alicia Rodríguez Gascón, Ana del Pozo-Rodríguez, María Ángeles Solinís
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