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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6639984/
Jul 16, 2019 · Drug delivery. Using the delivery capabilities of EVs for targeting of therapeutics to specific cells and tissues, for example, in the delivery of therapeutic RNAs. The latter subject, drug delivery with EVs, is the topic of this Account.Author: Olivier G. de Jong, Sander A. A. Kooijmans, Daniel E. Murphy, Linglei Jiang, Martijn J. W. Evers, Jo...
https://www.sciencedirect.com/science/article/pii/S0169409X1830262X
Examples of vesicle drug delivery systems including non-conventional amphiphiles or hierarchical assemblies, which deliver a payload in response to heat, light, ultrasound and mechanical forces.Author: Ulrike Kauscher, Margaret N. Holme, Mattias Björnmalm, Molly M. Stevens
https://pubs.acs.org/doi/pdf/10.1021/acs.accounts.9b00109
extracellular vesicle activity and should improve translation into clinical application of engineered extracellular vesicles as a new class of drug delivery systems. EXTRACELLULAR VESICLES “Extracellular vesicles” is an umbrella term for the small sub-micrometer-sized particles composed of lipid membranes that all cells release.
http://www.imedpub.com/articles/vesicular-systemcarrier-for-drug-delivery.pdf
vesicular drug delivery systems. Vesicular drug delivery system has some of the advantages like: 1. Prolong the existence of the drug in systemic circulation, and perhaps, reduces the toxicity if selective uptake can be achieved due to the delivery of drug directly to the site of infection. 2.Author: Ravi Kumar, Shivjee Kumar, Shyam Shankar Jha, Amit Kumar Jha
https://www.hindawi.com/journals/ap/2014/574673/
Vesicular drug delivery system sustains drug action at a predetermined rate, relatively constant (zero order kinetics), efficient drug level in the body, and simultaneously minimizes the undesirable side effects. It can also localize drug action in the diseased tissue or organ by targeted drug delivery using carriers or chemical derivatization.Author: Shikha Jain, Vikas Jain, S. C. Mahajan
https://www.exosome-rna.com/extracellular-vesicles-for-drug-delivery/
Nov 01, 2016 · Extracellular vesicles (EVs) are cell-derived membrane vesicles, and represent an endogenous mechanism for intercellular communication. Since the discovery that EVs are capable of functionally transferring biological information, the potential use of EVs as drug delivery vehicles has gained considerable scientific interest.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857056/
Oct 17, 2019 · Liposomes are versatile drug delivery vehicles, as both the lipid membrane and interior space can be utilized for loading of hydrophobic and hydrophilic drugs, respectively. Similarly, EVs can be utilized as drug carriers for both water-soluble and non-water-soluble therapeutic agents.Author: Sierra Walker, Sara Busatto, Anthony Pham, Ming Tian, Annie Suh, Kelsey Carson, Astrid Quintero, Mar...
https://www.sciencedirect.com/science/article/pii/S0169409X1830156X
Extracellular vesicles (EVs), sub-micron vectors used in intercellular communication, have demonstrated great promise as natural drug delivery systems. Recent reports have detailed impressive in vivo results from the administration of EVs pre-loaded with therapeutic cargo, including small molecules, nanoparticles, proteins and oligonucleotides. These results have sparked intensive research interest …Author: James P.K. Armstrong, Molly M. Stevens
https://www.sciencedirect.com/science/article/pii/S0168365914005434
Drug delivery by liposomes is mainly attributed to their ability to circulate over longer periods leading to accumulation in tissues that are characterized by permeable vasculature, which facilitates extravasation of …Author: Roy van der Meel, Marcel H.A.M. Fens, Pieter Vader, Pieter Vader, Wouter W. van Solinge, Omolola Eni...
https://www.nature.com/articles/s41467-018-04791-8
Jun 15, 2018 · Here we sought to harness eukaryotes’ natural mechanism for RNA exchange and intercellular communication, the extracellular vesicles (EVs), to employ them as RNA drug delivery vehicles 6. The natural delivery of microRNAs and mRNAs by …Author: Waqas Muhammad Usman, Tin Chanh Pham, Yuk Yan Kwok, Luyen Tien Vu, Victor Ma, Boya Peng, Yuen San Ch...
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