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https://www.researchgate.net/publication/8531817_Vaccinia_as_a_vector_for_gene_delivery
Recombinant vaccinia virus (rVV) has been well developed as a gene delivery vector, initially for protein expression in mammalian cells. rVV has been further developed to express antigens in vivo in generating immunity for protection against specific infectious diseases and cancer.
https://www.tandfonline.com/doi/abs/10.1517/14712598.4.6.901
Apr 08, 2011 · Vaccinia as a vector for gene delivery. Gene therapy is a promising approach, yet so far it has shown limited effectiveness in many clinical trials, mainly due to insufficient gene transduction. Recombinant vaccinia virus (rVV) has been well developed as a gene delivery vector, initially for protein expression in mammalian cells.Author: Guo Zs, Bartlett Dl
https://www.nature.com/articles/7700075
May 18, 2000 · Vaccinia as a vector for tumor-directed gene therapy: Biodistribution of a thymidine kinase-deleted mutant. Abstract. Tumor-directed gene therapy, such as “suicide gene” therapy, requires high levels of gene expression in a high percentage of tumor cells in vivo to be effective.Author: Markus Puhlmann, Charles K Brown, Michael Gnant, James Huang, Steven K Libutti, H Richard Alexander,...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3207353/
Viruses can also be used as vectors for gene delivery (Table 1). For example, adenoviral vectors have been engineered to express suicide genes, such as herpes simplex virus-1 (HSV-1) thymidine kinase (TK), 9 which renders target cells expressing the transgene susceptible to treatment with gancyclovir. 10 Viruses have also been used as oncolytic agents.Author: Cecilia Larocca, Jeffrey Schlom
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417261/
Mar 12, 2019 · The successful gene delivery system requires the foreign genetic molecule to remain stable within the host cells [6–8]. As a tool of transgene expression, viral-based vectors had firstly emerged in the 1980’s . The virus as a vaccine vector was used the vaccinia virus in 1984 as a way to protect chimpanzees against Hepatitis B .Author: YK Sung, SW Kim
https://www.thermofisher.com/us/en/home/references/gibco-cell-culture-basics/transfection-basics/gene-delivery-technologies/viral-delivery/viral-vectors.html
Other viral vector systems that can be used for overexpression of proteins include vectors based on baculovirus, vaccinia virus, and herpes simplex virus.While baculoviruses normally infect insect cells, recombinant baculoviruses can serve as gene-transfer vehicles for transient expression of recombinant proteins in a wide range of mammalian cell types.
https://www.nature.com/articles/3302840
Aug 17, 2006 · Phase i study of intravesicle vaccinia virus as a vector for gene therapy of bladder cancer. J Urol ... Tumor-specific gene delivery using recombinant vaccinia virus in a …Author: Chien-Fu Hung, Y. C. Tsai, L. He, G. Coukos, I. Fodor, L. Qin, H. Levitsky, Tzyy Choou Wu
https://www.creative-biolabs.com/gene-therapy/herpes-simplex-virus-vector.htm
The HSV vector possesses a double stranded linear genome of 150kb and due to its neurotrophic nature, it has the greatest potential for gene delivery to the nervous system and tumor cells. The HSV-1 vector does not integrate into the host genome, resulting in transient expression in infected cells.
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