Vaccinia Virus Gene Delivery

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Viral and nonviral delivery systems for gene delivery

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507026/
    Jul 06, 2012 · Viral and nonviral delivery systems for gene delivery. ... There are different viral and nonviral vectors for gene delivery, but all gene therapy applications depend on the fact that the genetic material needs to be delivered across the cell membrane and ultimately to the cell nucleus. ... These are derived from vaccinia virus, human ...

Tumor-Specific Gene Delivery Using Recombinant Vaccinia ...

    https://academic.oup.com/jnci/article/91/20/1744/2543860
    Oct 20, 1999 · Anti-vector antibodies were detectable in serum as early as day 6 and were maintained for more than 3 months. CONCLUSIONS: Tumor-specific gene delivery is possible after systemic injection of a thymidine kinase-negative vaccinia virus vector in a model of rabbit liver metastases.Author: Michael F. X. Gnant, Linda A. Noll, Kari R. Irvine, Markus Puhlmann, Richard E. Terrill, H. Richard ...

A marker-free system for highly efficient construction of ...

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4571730/
    Sep 16, 2015 · The current method for creation of vaccinia virus (VACV) vectors involves using a selection and purification marker, however inclusion of a gene without therapeutic value in the resulting vector is not desirable for clinical use. The Cre-LoxP system has ...Author: Ming Yuan, Xuefei Gao, Louisa S Chard, Zarah Ali, Jahangir Ahmed, Yunqing Li, Pentao Liu, Nick R Lem...

Targeted delivery of a suicide gene to human colorectal ...

    https://www.nature.com/articles/gt200882
    May 15, 2008 · Targeted delivery of a suicide gene to human colorectal tumors by a conditionally replicating vaccinia virus Skip to main content Thank you for visiting nature.com.Author: Foloppe J, Kintz J, Futin N, Findeli A, Cordier P, Schlesinger Y, Hoffmann C, Tosch C, Balloul Jm, E...

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