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https://www.sciencedirect.com/science/article/pii/S037851730700840X
The delivery system was biocompatible and biodegradable. Thus, PLGA–PEG–PLGA (MW 1400–1000–1400) is a good polymer for developing long-acting controlled release injectable solution delivery system for growth hormone.Author: Sibao Chen, Jagdish Singh
https://pubs.acs.org/doi/pdf/10.1021/acsomega.8b02781
biodegradable polymers became popular for their ease of administration, lack of surgery for implantation and removal, and biocompatibility.31−33 Here, we present the formulation development of a thermosensitive triblock copolymer-based delivery system releasing sCT in its active conformation in a controlled
https://www.researchgate.net/publication/6319586_Thermosensitive_polymers_Synthesis_characterization_and_delivery_of_proteins
Thermosensitive polymers: Synthesis, characterization, and delivery of proteins Article in International Journal of Pharmaceutics 341(1-2):68-77 · August 2007 with 30 Reads How we measure 'reads'
https://www.sciencedirect.com/science/article/abs/pii/S002235491532520X
Thermosensitive and phase sensitive polymer formulations significantly (p < 0.05) increased relative bioavailability of steroidal hormones compared to control. In conclusion, thermosensitive and phase sensitive polymer based delivery systems controlled the release in vivo in rabbits for longer duration after single s.c. injection.Author: Sibao Chen, Daniel Pederson, Mayura Oak, Jagdish Singh
https://www.sciencedirect.com/science/article/pii/S016836591000653X
Injectable, biodegradable, and thermosensitive hydrogels can be an alternative protein delivery system of the microsphere. Their high water content and temperature dependent gelation without organic solvents or chemical cross-linkers make them compatible as a protein delivery carrier [20], [21].Author: Mi-Ran Park, Mi-Ran Park, ChangJu Chun, Sung-Won Ahn, Min-Hyo Ki, Chong-Su Cho, Soo-Chang Song
https://www.tandfonline.com/doi/abs/10.1081/PDT-54479
Dec 14, 2012 · The objective of this research is to develop injectable controlled delivery systems for the contraceptive hormone, levonorgestrel (LNG), using phase sensitive and thermosensitive polymers. A combination of poly (lactide) (PLA) and a solvent mixture of benzyl benzoate (BB) and benzyl alcohol (BA) was used in the phase-sensitive polymer delivery systems.Author: Sibao Chen, Jagdish Singh
https://www.sciencedirect.com/science/article/pii/S0142961209011090
PLGA is a biodegradable polymer and approved in market for sustained release formulation of peptides such as luteinizing hormone-releasing hormone (LHRH) analogues , . However, developing sustained release formulation of proteins including hGH has been hampered due to their complex structure which is related to protein activity.Author: Mi-Ran Park, Mi-Ran Park, ChangJu Chun, Sung-Won Ahn, Min-Hyo Ki, Chong-Su Cho, Soo-Chang Song
https://www.researchgate.net/publication/5810438_Controlled_release_of_growth_hormone_from_thermosensitive_triblock_copolymer_systems_In_vitro_and_in_vivo_evaluation
Controlled delivery systems based on thermosensitive gels are easy to prepare, low cost and high versatility dosage forms, which have been shown to be effective in several animal species for...
https://www.researchgate.net/publication/41827205_In_Vivo_Absorption_of_Steroidal_Hormones_from_Smart_Polymer_Based_Delivery_Systems
Thermosensitive and phase sensitive polymer formulations significantly (p < 0.05) increased relative bioavailability of steroidal hormones compared to control. In conclusion, thermosensitive and...
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