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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4516168/
Biodegradable and injectable in situ thermosensitive hydrogels were investigated for sustained delivery of protein therapeutics in the treatment of ocular posterior segment neovascular diseases.Author: Sulabh P. Patel, Ravi Vaishya, Xiaoyan Yang, Dhananjay Pal, Ashim K. Mitra
https://www.mdpi.com/journal/polymers/sectioneditors/Bio
Smart polymeric materials: synthesis of thermosensitive polymers, phase transition, and conformational changes. Controlled chemical modification of polysaccharides, including the use of "click" chemistry reactions. Functional polymeric materials and nanomaterials for …
https://pubs.acs.org/doi/10.1021/acsomega.8b02781
Controlled-release delivery systems, particularly subcutaneous depot systems help overcome this hurdle by making the dosing regimen easy, convenient, and consistent. To this end, we have developed and characterized a PEG–PLGA-based thermosensitive triblock copolymer for controlled delivery of …
http://www.eurekaselect.com/openurl/content.php?genre=article&issn=0929-8665&volume=21&issue=11&spage=1185
Title:Novel Thermosensitive Pentablock Copolymers for Sustained Delivery of Proteins in the Treatment of Posterior Segment Diseases VOLUME: 21 ISSUE: 11 Author(s):Sulabh P. Patel, Ravi Vaishya, Xiaoyan Yang, Dhananjay Pal and Ashim K. Mitra Affiliation:Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, Kansas City, Missouri-64108, USA.
http://www.eurekaselect.com/93082
Abstract: Protein and peptide-based therapeutic agents have unique physiochemical properties such as high molecular weight, short half life, requirement of a sustained plasma level for the desired therapeutic effect, liable to physical and chemical instability by gastric enzymes and harsh acidic environment as well as first pass metabolism, which makes their delivery a challenge.
https://www.mdpi.com/2073-4360/7/8/1467/htm
The purpose of this study was to investigate the effects of size and type of incorporated model molecules on the polymer degradation and release profile from thermosensitive triblock copolymer based controlled delivery systems. In vitro release of the incorporated molecules demonstrated slow release for risperidone (molecular weight (Mw) = 410.48 Da; partition coefficient (Ko/w) = 3.49), while ...
https://www.ingentaconnect.com/content/ben/ddf/2009/00000003/00000001/art00004
Use of control delivery for these drugs using smart polymers seems promising as they overcome the limitations posed by other routes of delivery. Smart polymers increase patient compliance, maintain stability of the drug, and maintain drug level in therapeutic window and are easy to manufacture.
http://www.ijpmr.org/pdf/Thermosensitive-hydrogel-an-inventive%20-carrier-for-drug-delivery.pdf
Controlled drug delivery systems, which are intended to deliver ... Structure of thermosensitive polymers ... proteins, etc.) as well as the need for their removal before application. Careful selection of hydrocolloid type, concentration and pH can lead to the formation
https://link.springer.com/article/10.1023/A:1023887203111
Purpose. Currently, most pDNA delivery systems based on synthetic polymers are either nonbiodegradable or not sensitive to the release environment. The primary objective of this study was to develop and evaluate an aqueous-based, thermosensitive, biodegradable and biocompatible triblock copolymer to control pDNA delivery in vitro and in vivo.
http://scialert.net/fulltext/?doi=ijp.2006.513.519
Thermo-sensitive Polymers for Controlled-release Drug Delivery Systems. Li Jun , Wang Bochu and Wang Yazhou : ABSTRACT. In recent years, thermo-sensitive polymer as a novel carrier for controlled-release drug delivery systems has been widely concerned by researchers. With respect to thermo-sensitive polymer, Researchers study on its properties ...
http://europepmc.org/articles/PMC4516168
Novel Thermosensitive Pentablock Copolymers for Sustained Delivery of Proteins in the Treatment of Posterior Segment Diseases Sulabh P. Patel , Ravi Vaishya , Xiaoyan Yang , …
http://europepmc.org/articles/PMC2818050/
The thermogelling polymers have consistently achieved controlled drug delivery via in situ depot formation . Not only the release of small molecule drugs but also the release of macromolecules such as proteins, chondrocytes, plasmid DNA has been controlled with the thermogelling polymers [8, 10, 18].
https://www.linkedin.com/in/mayuraoak
Thermosensitive polymers for controlled delivery of hormones ... Thermosensitive polymers for controlled delivery of proteins Nova Science Publishers, Inc January 1, 2009.Title: Formulation Scientist II (Specialty …
https://journals.sagepub.com/doi/abs/10.1177/0883911513517781
The thermosensitive polyelectrostatic complex had prolonged in vivo stability that was greater than the polyelectrostatic complex. Based on stability and bioactivity tests for the lysozyme-loaded thermosensitive polyelectrostatic complexes, the potential of the long-term protein delivery carrier in physiological conditions was confirmed.
https://experts.umn.edu/en/publications/macromolecular-diffusion-in-self-assembling-biodegradable-thermos
title = "Macromolecular diffusion in self-assembling biodegradable thermosensitive hydrogels", abstract = "Hydrogel formation triggered by a change in temperature is an attractive mechanism for in situ gelling biomaterials for pharmaceutical applications such as the delivery of therapeutic proteins.
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