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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3436072/
Jun 30, 2011 · The use of ultrasound for the delivery of drugs to, or through, the skin is commonly known as sonophoresis or phonophoresis. The use of therapeutic and high frequencies of ultrasound (≥ 0.7 MHz) for sonophoresis (HFS) dates back to as early as the 1950s, while low-frequency sonophoresis (LFS, 20 – 100 kHz) has only been investigated significantly during the past two decades.Author: Baris E. Polat, Douglas Hart, Robert Langer, Daniel Blankschtein
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2676802/
Ultrasound enhanced transdermal drug delivery offers advantages over traditional drug delivery methods which are often invasive and painful. A broad review of the transdermal ultrasound drug delivery literature has shown that this technology offers promising potential for noninvasive drug administration.Author: Nadine Barrie Smith
https://www.sciencedirect.com/science/article/pii/S0169409X14000088
Transdermal drug delivery offers an attractive alternative to the conventional drug delivery methods of oral administration and injections. However, the stratum corneum serves as a barrier that limits the penetration of substances to the skin.Author: Aharon Azagury, Luai Khoury, Giora Enden, Joseph Kost
https://www.researchgate.net/publication/305317105_A_Review_on_Ultrasound_Parameters_and_Methods_of_Application_in_Transdermal_Drug_Delivery
The transdermal route of drug delivery has attracted medical and pharmacological researchers due to its advantages over other methods of drug delivery. ... The use of ultrasound for the delivery ...
https://www.sciencedirect.com/science/article/pii/S1359644604031708
Application of ultrasound to the skin increases its permeability (sonophoresis) and enables the delivery of various substances into and through the skin. This review presents the main findings in the field of sonophoresis, namely transdermal drug delivery and transdermal monitoring.Author: Ilana Lavon, Joseph Kost
https://www.researchgate.net/publication/261759007_TRANSDERMAL_DRUG_DELIVERY_SYSTEM_A_REVIEW
Transdermal drug delivery has made an important contribution to medical practice, but it has yet to fully achieve its potential as an alternative to the oral delivery and hypodermic injections.
https://www.nature.com/articles/nbt.1504
Nov 07, 2008 · Transdermal drug delivery has made an important contribution to medical practice, but has yet to fully achieve its potential as an alternative to oral delivery and hypodermic injections. First ...Author: Mark R Prausnitz, Robert Langer
https://www.nature.com/articles/s41598-020-61328-0
Mar 09, 2020 · Pressure waves generated by ultrasound (US) have been employed to enhance transdermal drug delivery (TDD) for many years 1.In 2004, US at 20–100 kHz was approved by the United States FDA for the ...Author: Ai-Ho Liao, Ai-Ho Liao, Keng-Hsien Lin, Ho-Chiao Chuang, Chih-Hung Tsai, Yi-Chun Lin, Chih-Hung Wang...
https://www.medgadget.com/2005/06/ultrasound_for.html
Dermisonics is a company that uses ultrasound to enhance transdermal drug penetration:. An alternating ultrasonic waveform enlarges the diameter of the skin pores and enables large molecule drugs ...
https://science.sciencemag.org/content/269/5225/850
Aug 11, 1995 · Transdermal drug delivery offers a potential method of drug administration. However, its application has been limited to a few low molecular weight compounds because of the extremely low permeability of human skin. Low-frequency ultrasound was shown to increase the permeability of human skin to many drugs, including high molecular weight proteins, by several orders of magnitude, thus …Author: S Mitragotri, D Blankschtein, R Langer
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