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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2626933/
Since the beginning of the 90s, Elan Nanosystems (San Francisco, CA, USA) propagated the use of nanocrystals instead of microcrystals for oral bioavailability enhancement, but also to use nanocrystals suspended in water (nanosuspensions) for intravenous or pulmonary drug delivery.Author: Jens-Uwe A H Junghanns, Rainer H Müller
https://www.pharmaceuticalonline.com/doc/first-us-approval-for-elans-nanocrystal-formu-0001
Aug 30, 2000 · FDA's action represents the first approval for a drug using NanoCrystal, which in tablet form provides easier administration and storage than the currently marketed Rapamune oral solution. Developed by Elan's Elan Pharmaceutical Technologies' (EPT) division, NanoCrystal technology enables efficient delivery of drugs that are poorly water-soluble.
https://www.researchgate.net/publication/274960213_Stabilizers_used_in_nanocrystal_based_drug_delivery_system
Stabilizers used in nanocrystal based drug delivery system Article (PDF Available) in Journal of Excipients and Food Chemicals 5(4):184-209 · December …
https://www.slideshare.net/drshereenshehata/nanocrystals
Jan 26, 2017 · Nanocrystals 1. • Nanocrystals are pure solid drug particles with a size in the nanometer range. • Drug nanocrystals have to be distinguished from polymeric nanoparticles, which consist of a polymeric matrix and an incorporated drug but drug nanocrystals do not consist of any matrix material.
https://www.researchgate.net/publication/275226328_Nanocrystal_technology_for_drug_formulation_and_delivery
The simplicity in preparation and the potential for various administration routes allow drug nanocrystals to be a novel drug delivery system for specific diseases (i.e. cancer). In addition to the ...
https://www.scholarsresearchlibrary.com/articles/nanocrystal-technology-a-particle-engineering-formulation-strategy-for-the-poorly-water-soluble-drugs.pdf
Nanocrystal technology: A particle engineering formulation strategy for the ... This is suitable drug delivery system for all commonly used routes of administration such as oral, IV, SC, and IM and topical application. ... drug nanocrystals are nanoparticles being composed of 100% drug without any matrixAuthor: Vishal V. P, Vidya N. Abhale
https://www.fiercepharma.com/special-report/nanocrystals-when-nanotech-meets-biotech
Apr 18, 2011 · For the past decade or so, Elan Drug Technologies, the drug delivery unit of Irish drugmaker Elan, has been working on, and perfecting, its NanoCrystal technology, which essentially is a …
https://onlinelibrary.wiley.com/doi/full/10.1111/j.2042-7158.2010.01022.x
Jul 20, 2010 · Drug nanocrystals are nanoparticles containing 100% drug without any matrix material. A stabilizing agent is situated on the surface of the drug particles. The drug delivery route and its limitations should be taken into account in the selection of the stabilizer.Author: Leena Peltonen, Jouni Hirvonen
https://www.businesswire.com/news/home/20040420006362/en/Elan-Licenses-NanoCrystal-Technology-Roche
Apr 21, 2004 · April 21, 2004-- Proprietary Elan technology helps improve drug delivery by transforming drugs into more. Elan Licenses Its NanoCrystal Technology to Roche. April 21, 2004 01:30 AM Eastern ...
http://www.americanpharmaceuticalreview.com/Featured-Articles/331624-Drug-Nanocrystal-Technologies-for-Oral-Drug-Delivery/
Dec 01, 2016 · Juniper Pharma Services; The milling of drug substances to reduce particle size is a common process used in the pharmaceutical industry. Reducing particle size helps achieve uniform distribution of the drug when blended with excipients, which is especially important for low dose products (drug content < 5% w/w).
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