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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4015834/
Oct 24, 2013 · Design considerations of HPMA-peptide polymers for gene delivery. Salt stability is necessary for the systemic administration of polyplexes since polyplex aggregation can lead to in vivo toxicity .Author: Julie Shi, Joan G Schellinger, Suzie H Pun
https://jbioleng.biomedcentral.com/articles/10.1186/1754-1611-7-25
Oct 24, 2013 · The relatively simple polymerization strategy used to synthesize these polymers has allowed the investigation of peptide multivalency, polymer architecture, and the use of various bioactive peptides for gene delivery applications.Author: Julie Shi, Joan G Schellinger, Suzie H Pun
https://www.ncbi.nlm.nih.gov/pubmed/24156736
Oct 24, 2013 · In this review, we summarize our work over the last five years in developing a modular approach for synthesizing peptide-based polymers. In these materials, bioactive peptides that address various barriers to gene delivery are copolymerized with a hydrophilic backbone of N-(2-hydroxypropyl)methacrylamide (HPMA) using reversible-addition fragmentation chain-transfer (RAFT) polymerization.Author: Julie Shi, Joan G Schellinger, Suzie H Pun
https://www.researchgate.net/publication/258042387_Engineering_biodegradable_and_multifunctional_peptide-based_polymers_for_gene_delivery
Engineering biodegradable and multifunctional peptide-based polymers for gene delivery Article (PDF Available) in Journal of Biological Engineering 7(1):25 · October 2013 with 171 Reads
https://www.academia.edu/36453290/Engineering_biodegradable_and_multifunctional_peptide-based_polymers_for_gene_delivery
Engineering biodegradable and multifunctional peptide-based polymers for gene delivery
https://pubs.acs.org/doi/10.1021/bc9003662
These peptides were copolymerized with HPMA to form biodegradable, DNA-condensing copolymers for gene delivery. The polymerization conditions were optimized by varying the initiator to monomer ratios, macromonomer to comonomer ratios, and reactant concentrations.
https://pubs.acs.org/doi/10.1021/ar200248u
Multifunctional Dendronized Peptide Polymer Platform for Safe and Effective siRNA Delivery. ... Exploring the role of peptides in polymer-based gene delivery. Acta Biomaterialia 2017, 60, 23-37. DOI: 10.1016/j.actbio.2017.07.043. ... Arginine-Grafted Biodegradable Polymer: A Versatile Transfection Reagent for both DNA and siRNA.Author: Sejin Son, Ran Namgung, Jihoon Kim, Kaushik Singha, Won Jong Kim
http://onlinelibrary.wiley.com/doi/10.1002/app.34156/abstract
May 31, 2011 · 6 Julie Shi, Joan G Schellinger, Suzie H Pun, Engineering biodegradable and multifunctional peptide-based polymers for gene delivery, Journal of Biological Engineering…
https://www.degruyter.com/view/j/ejnm.2015.7.issue-2/ejnm-2014-0037/ejnm-2014-0037.xml
Apr 01, 2015 · The use of naturally occurring and/or synthetic peptides whose designs are based upon viral sequences, therefore present an attractive alternative for nucleic acid delivery. Multi-functional peptide-based nanoparticles comprising distinct motifs with specific functionalities designed to overcome the extra- and intra-cellular barriers could, in theory, be used for safe and efficient gene delivery …Author: Stephen Patrick Loughran, Cian Michael McCrudden, Helen Olga McCarthy
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