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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4026551/
May 10, 2014 · In addition, the brain delivery of colloidal drug carriers can be further enhanced by conjugation to specific targeting agents. Targeted delivery methods independent of the ligand–receptor interactions on the cell surface are currently being used for brain delivery of drugs.Author: Cui-Tao Lu, Ying-Zheng Zhao, Ho Lun Wong, Jun Cai, Lei Peng, Xin-Qiao Tian
http://www.pharmtech.com/enhanced-brain-drug-delivery-and-targeting
Enhanced brain drug delivery and targeting An examination of the drug analogs and prodrugs of small molecules that utilize either large neutral amino acid or glucose transporters of the BBB in their brain penetration. Apr 01, 2008 By Mikko Gynther, Jarkko Rautio, Krista Laine
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629063/
Apr 05, 2014 · Receptor-mediated transcytosis is considered one of the most mature strategies for brain targeted drug delivery with the characteristics of high specificity, selectivity and affinity, although the ligand may have an effect on homeostasis and natural ligands may compete with the drug ligand to reduce targeting efficiency.Author: Xiaoli Wei, Xishan Chen, Man Ying, Weiyue Lu
https://www.sciencedirect.com/book/9780128140017/brain-targeted-drug-delivery-system
Brain targeting drug delivery has been gained increasing attention in the past decade, and many strategies were developed to improve the brain targeting drug delivery by fabricating various nanoparticles-based drug delivery systems. Although impressive progress has been made, the drug delivery efficiency is still far from satisfactory.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4493051/
Although many of the constituent cells and molecules of the BBB manifest throughout the body, in the brain they are combined into a unique construction that severely restricts entry into the brain. Improved drug delivery stands to enhance existing treatments, mediate tumor recurrence, and provide an opportunity to therapeutically target tumors not amenable to resection.Author: Tej D. Azad, James Pan, Ian D. Connolly, Austin Remington, Christy M. Wilson, Gerald A. Grant
https://www.nature.com/articles/s41467-018-04315-4
May 18, 2018 · Transferrin-functionalized nanoparticles cross the intact BBB. a Schematic of a PEGylated dual drug-loading liposome that can be functionalized to enhance transport across the BBB and targeting to...Author: Fred C. Lam, Stephen W. Morton, Jeffrey Wyckoff, Tu-Lan Vu Han, Mun Kyung Hwang, Amanda Maffa, Elena...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4392984/
May 21, 2013 · In particular, the rationale of using NPs for brain drug delivery is that proper surface multifunctionalization may promote at the same time either their targeting of the BBB or the enhancement of its crossing. The possibility for BBB-impermeant drugs to reach the brain, when vehicled by NPs,...Author: Massimo Masserini
https://www.researchgate.net/publication/279408805_Brain_targeting_Drug_Delivery_System_A_Review
Among drug carrier system, Nanoparticles exhibit an impressive attention in the field of targeted drug delivery system because of possessing solid colloidal particles with a size range between 1- 1000nm. Gradual drug release reduced peripheral toxicity and potential to target specific brain sites by...
https://www.slideshare.net/sayedasalma/brain-specific-delivery
Jul 24, 2018 · • Drug delivery to the brain is the process of passing therapeutically active molecules across the Blood Brain Barrier for the purpose of treating brain maladies. • This is a complex process that must take into account the complex anatomy of the brain as well as the restrictions imposed by the special junctions of the Blood Brain Barrier.
https://www.slideshare.net/shivadheeraj/brain-targeting-14689173
Oct 11, 2012 · Molecular packaging: brain delivery of NeuropeptidesDelivery of peptides through the BBB is even more challenging thandelivery of other drugs, because peptides tend to be rapidly inactivatedby the ubiquitous peptidases.For a successful delivery, three issues have to be solved simultaneously: enhance passive transport by increasing the lipophilicity, ensure enzymatic stability to prevent premature degradation, and exploit the lock-in mechanism to provide targeting.Successful brain deliveries ...
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