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https://www.researchgate.net/publication/9034597_Emerging_Trends_in_Oral_Delivery_of_Peptide_and_Protein_Drugs
Emerging Trends in Oral Delivery of Peptide and Protein Drugs Article · Literature Review (PDF Available) in Critical Reviews in Therapeutic Drug Carrier Systems 20(2-3):153-214 · February 2003 ...
https://www.ncbi.nlm.nih.gov/pubmed/14584523
Emerging trends in oral delivery of peptide and protein drugs. Mahato RI(1), Narang AS, Thoma L, Miller DD. Author information: (1)Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA. [email protected]: Ram I. Mahato, Ajit S. Narang, Laura Thoma, Duane D. Miller
https://www.researchgate.net/profile/Duane_Miller2/publication/9034597_Emerging_Trends_in_Oral_Delivery_of_Peptide_and_Protein_Drugs/links/5492f4620cf2213b86cba787/Emerging-Trends-in-Oral-Delivery-of-Peptide-and-Protein-Drugs.pdf
Emerging Trends in Oral Delivery of Peptide and Protein Drugs Ram I. Mahato, Ajit S. Narang, Laura Th oma, & Duane D. Miller Department of Pharmaceutical Sciences, University of Tennessee Health ...
http://dl.begellhouse.com/journals/3667c4ae6e8fd136,1124852a097c6181,016bae445382e20a.html
Development of an effective oral delivery system for these macromolecular drugs requires a thorough understanding of their physicochemical properties, such as molecular weight, hydrophobicity, ionization constants, and pH stability, as well as biological barriers that restrict protein and peptide absorption from the gastrointestinal (GI) tract ...
https://nebraska.pure.elsevier.com/en/publications/emerging-trends-in-oral-delivery-of-peptide-and-protein-drugs
Most peptide and protein drugs are currently used as parenteral formulations because of their poor oral bioavailability. Development of an effective oral delivery system for these macromolecular drugs requires a thorough understanding of their physicochemical properties, such as molecular weight, hydrophobicity, ionization constants, and pH stability, as well as biological barriers that ...Author: Ram I. Mahato, Ajit S. Narang, Laura Thoma, Duane D. Miller
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2792531/
The main challenge is to improve the oral bioavailability from less than 1% to at least 30-50%. Consequently, efforts have intensified over the past few decades, where every oral dosage form used for the conventional small molecule drugs has been used to explore oral protein and peptide delivery.
https://link.springer.com/article/10.2165/00063030-200519030-00003
Aug 15, 2012 · The main reasons for the low oral bioavailability of peptide drugs are pre-systemic enzymatic degradation and poor penetration of the intestinal mucosa. A considerable amount of research has focused on overcoming the challenges presented by these intestinal absorption barriers to provide effective oral delivery of peptide and protein drugs.Author: Josias H. Hamman, Gill M. Enslin, Awie F. Kotzé
https://link.springer.com/article/10.1208/s12249-019-1325-z
May 20, 2019 · The status, advantages, and disadvantages of various strategies are systematically analyzed. The systematic and personalized design of various factors affecting the release and absorption of drugs based on nanoparticles is pointed out. It is expected to design a protein peptide oral delivery system that can be applied in the clinic.Author: Shu-jun Cao, Shuo Xu, Hui-ming Wang, Yong Ling, Jiahua Dong, Rui-dong Xia, Xiang-hong Sun
http://www.iptonline.com/articles/public/IPTNINE106NoPrint.pdf
The oral delivery of protein and peptide drugs A variety of strategies can be used to overcome the barriers to protein/ peptide drug delivery by the oral route. Dr Richard Soltero and Dr Nnochiri Ekwuribe, Nobex Corporation T he use of polypeptides and proteins forFile Size: 228KB
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