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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3358486/
May 22, 2012 · Enhanced Delivery of Chemotherapy to Tumors Using a Multi-Component Nanochain with Radiofrequency-Tunable Drug Release. ... low. Of course, there are reasons other than tumor dosing and drug transport in the tumor interstitium that govern tumor responsiveness to chemotherapy.Author: Pubudu M. Peiris, Lisa Bauer, Randall Toy, Emily Tran, Jenna Pansky, Elizabeth Doolittle, Erik Schmi...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4138219/
May 13, 2014 · A Nanoparticle-Based Combination Chemotherapy Delivery System for Enhanced Tumor Killing by Dynamic Rewiring of Signaling Pathways. ... Folate is a commonly used ligand for targeted cancer delivery because it enhances delivery of therapeutics to tumor cells on which folate receptor a is abundant at the cell surface.Author: Stephen W. Morton, Michael J. Lee, Zhou J. Deng, Erik C. Dreaden, Elise Siouve, Kevin E. Shopsowitz,...
https://braintumorcenter.ucsf.edu/treatment/experimental-diagnostics-therapies/convection-enhanced-delivery
To address this problem, researchers at UCSF and elsewhere have been developing a procedure called convection-enhanced delivery (CED). CED is an experimental technique for directly infusing drugs into a brain tumor. This increases drug efficacy while reducing side effects to healthy brain tissue and the rest of …
https://my.clevelandclinic.org/health/treatments/16801-chemotherapy
Convection Enhanced Delivery. One treatment approach that shows much promise is called convection enhanced delivery. In this method, drugs are infused directly into the brain tumor using one or more special catheters implanted in or near the tumor. The catheters deliver drug under pressure (convection) over 48-72 hours as if on a wave.
https://www.sciencedirect.com/science/article/pii/S0168365912005809
Sep 28, 2012 · Chemotherapy-induced apoptosis of tumor cells enhances the antigen presentation and sensitizes tumor cells to T cell-mediated cytotoxicity. Here we harnessed the apoptosis of tumor cells as a homing signal for the delivery of T cells to tumor.Author: Xiaofeng He, Napolean Bonaparte, Soyoun Kim, Bodhraj Acharya, Ji Young Lee, Lianhua Chi, Hyoung Joo ...
https://www.sciencedirect.com/science/article/pii/S0142961220301691
Chemotherapy remains one of the most important ways to treat cancer. However, tumor microenvironment (TME) usually hold the characteristics of hypoxia, high concentration of H 2 O 2, glucose deprivation, and low pH, which directly affect the chemotherapy effect of cancer to a …Author: Xufeng Zhu, Youcong Gong, Yanan Liu, Chunhua Yang, Sijie Wu, Guanglong Yuan, Xian Guo, Jie Liu, Xiuy...
https://clinicaltrials.gov/ct2/show/NCT02278510
To investigate by MR imaging the spatial and temporal distribution of topotecan in tumor and tumor-infiltrated brain administered by convection-enhanced delivery (CED) in patients with recurrent/progressive WHO grade III or IV (high grade) glioma (HGG) who have failed standard therapy comprising surgical biopsy and/or resection and adjuvant ...
https://pubs.acs.org/doi/10.1021/acs.nanolett.8b03905
Amplification of Tumor Oxidative Stresses with Liposomal Fenton Catalyst and Glutathione Inhibitor for Enhanced Cancer Chemotherapy and Radiotherapy Ziliang Dong Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Institute of Functional Nano and Soft Materials (FUNSOM), Soochow University, 199 Ren’ai Road, Suzhou 215123 ...Author: Ziliang Dong, Liangzhu Feng, Yu Chao, Yu Hao, Muchao Chen, Fei Gong, Xiao Han, Rui Zhang, Liang Chen...
https://pubs.acs.org/doi/10.1021/bc200062q
Compared with PO−DOX and free DOX, Tf-PO−DOX demonstrated the strongest cytotoxicity against C6 glioma cells and the greatest intracellular delivery. It was shown in pharmacokinetic and brain distribution experiments that Tf-PO significantly enhanced brain delivery of DOX, especially the delivery of DOX into brain tumor cells.Author: Zhiqing Pang, Huile Gao, Yuan Yu, Liangran Guo, Jun Chen, Shuaiqi Pan, Jinfeng Ren, Ziyi Wen, Xinguo...
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