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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4725305/
Transdermal drug delivery. The top layer of the skin, the stratum corneum (SC), is a formidable diffusion barrier. Compared to oral drug delivery, transdermal drug delivery (TDD) allows circumvention of the first-pass effect and the delivery of drugs with low oral bioavailability without the …Author: Matthias A Oberli, Carl M Schoellhammer, Robert Langer, Daniel Blankschtein
https://www.ncbi.nlm.nih.gov/pubmed/30694397
Jan 29, 2019 · Enhanced Transdermal Drug Delivery by Sonophoresis and Simultaneous Application of Sonophoresis and Iontophoresis. Park J(1), Lee H(1), Lim GS(2), Kim N(2), Kim D(2), Kim YC(3). Author information: (1)Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea.Author: Juhyun Park, Hyowon Lee, Guei-Sam Lim, Nayoung Kim, Dongwon Kim, Yeu-Chun Kim
https://pubs.acs.org/doi/10.1021/acsnano.8b03800
Herein, we propose a paintable oligopeptide hydrogel containing paclitaxel (PTX)-encapsulated cell-penetrating-peptide (CPP)-modified transfersomes (PTX-CTs) to enhance transdermal PTX delivery for topical melanoma treatment.Author: Tianyue Jiang, Tong Wang, Teng Li, Yudi Ma, Shiyang Shen, Bingfang He, Ran Mo
https://pubs.acs.org/doi/abs/10.1021/acs.molpharmaceut.7b00111
Dissolving microneedle (DMN), a transdermal drug delivery system in which drugs are encapsulated in a biodegradable polymeric microstructure, is designed to dissolve after skin penetration and release the encapsulated drugs into the body. However, because of limited loading capacity of drugs within microsized structures, only a small dosage can be delivered, which is often insufficient for ...Author: Suyong Kim, Manita Dangol, Geonwoo Kang, Shayan F. Lahiji, Huisuk Yang, Mingyu Jang, Yonghao Ma, Che...
https://link.springer.com/article/10.1007/s11705-019-1913-1
Mar 06, 2020 · Transdermal delivery offers several advantages in drug distribution, including convenience, painless administration, avoidance of first-pass metabolism, an However, the natural protective barriers of the skin, such as the stratum corneum, the topmost layer of skin, limit the systemic absorption of external therapeutics via transdermal delivery.Author: Qiaofei Pan, Yinglin Yu, Dong Chen, Genlong Jiao, Xiaowen Liu
https://www.sciencedirect.com/science/article/pii/S1818087617303860
Transdermal delivery provides an optimal route for MLX to bypass the gastrointestinal adverse effects. In addition, MLX displays distinctive characteristics suitable for transdermal delivery, such as low dose, relatively low molecular weight (354.1), moderate lipophilicity (logP = 1.91 at pH 5.0), and excellent dermal tolerability.Author: Qin Yu, Xiying Wu, Quangang Zhu, Wei Wu, Zhongjian Chen, Ye Li, Yi Lu
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