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https://www.ncbi.nlm.nih.gov/pubmed/14584523
Development of an effective oral delivery system for these macromolecular drugs requires a thorough understanding of their physicochemical properties, such as molecular weight, hydrophobicity, ionization constants, and pH stability, as well as biological barriers that restrict protein and peptide absorption from the gastrointestinal (GI) tract, including pH variability, enzymatic degradation, and membrane efflux.Author: Ram I. Mahato, Ajit S. Narang, Laura Thoma, Duane D. Miller
http://dl.begellhouse.com/journals/3667c4ae6e8fd136,1124852a097c6181,016bae445382e20a.html
Development of an effective oral delivery system for these macromolecular drugs requires a thorough understanding of their physicochemical properties, such as molecular weight, hydrophobicity, ionization constants, and pH stability, as well as biological barriers that restrict protein and peptide absorption from the gastrointestinal (GI) tract, including pH variability, enzymatic degradation, and membrane efflux.
https://nebraska.pure.elsevier.com/en/publications/emerging-trends-in-oral-delivery-of-peptide-and-protein-drugs
Development of an effective oral delivery system for these macromolecular drugs requires a thorough understanding of their physicochemical properties, such as molecular weight, hydrophobicity, ionization constants, and pH stability, as well as biological barriers that restrict protein and peptide absorption from the gastrointestinal (GI) tract, including pH variability, enzymatic degradation, and membrane efflux.Author: Ram I. Mahato, Ajit S. Narang, Laura Thoma, Duane D. Miller
https://www.researchgate.net/publication/9034597_Emerging_Trends_in_Oral_Delivery_of_Peptide_and_Protein_Drugs
there are several physiological variables that infl uence, and more often than not. hinder, the oral bioavailability of protein and peptide drugs, such as gastric empty-. ing, transit time, the presence of food, variation in pH across the GI tract (pH 1~8), digestive enzymes, intestinal fl …
https://www.researchgate.net/profile/Duane_Miller2/publication/9034597_Emerging_Trends_in_Oral_Delivery_of_Peptide_and_Protein_Drugs/links/5492f4620cf2213b86cba787/Emerging-Trends-in-Oral-Delivery-of-Peptide-and-Protein-Drugs.pdf
oral bioavailability levels of most peptides and proteins are less than 1%. Several approaches are being applied to improve the oral absorption of peptide and protein drugs.
https://www.marketwatch.com/press-release/oral-proteins-and-peptides-market-3rd-edition-2018-2030-2018-05-08
May 08, 2018 · SCOPE OF THE REPORT The 'Oral Proteins and Peptides Market (3rd Edition), 2018-2030' report provides an extensive study on the current market landscape of orally administrable protein / peptide ...
http://asiapharmaceutics.info/index.php/ajp/article/viewFile/244/109
Proteins and peptides Proteins and peptides are the biopolymers which yield two or more amino acids on hydrolysis. Peptides and polypeptides are the principal components of the protoplasm of cells and are high molecular weight compounds consisting of alpha amino acids connected together by peptide linkages.[1-3] Proteins may have
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2792531/
Designing oral peptide and protein delivery systems has been a persistent challenge to pharmaceutical scientists because of their several unfavorable physicochemical properties including large molecular size, susceptibility to enzymatic degradation, short plasma half-life, ion permeability, immunogenicity, and the tendency to undergo aggregation, adsorption, and denaturation 12,13. Consequently, the absolute …
https://www.sciencedirect.com/science/article/pii/S1319016414000590
The current article deals with the possibilities being explored in the oral delivery of protein and peptide therapeutics, the challenges in their development and the current and future prospects, with focus on technology trends in the market to improve the bioavailability of proteins and peptides and effect of different forms of therapeutic proteins by oral routes.Author: Abdul Muheem, Faiyaz Shakeel, Mohammad Asadullah Jahangir, Mohammed Anwar, Neha Mallick, Gaurav Kuma...
http://www.iptonline.com/articles/public/IPTNINE106NoPrint.pdf
the other hand, oral and colonic delivery have the advantage of delivering drugs through the intestinal tract to the hepatic portal vein, and then to the systemic circulation. The ease of administration and higher degree of patient compliance with oral dosage forms are the major reasons for preferring to deliver proteins and peptides by mouth.File Size: 228KB
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