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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3436072/
Jun 30, 2011 · From these beginnings, research on low-frequency ultrasound-mediated transdermal drug delivery has exploded, with dozens of different groups working on applications of this technology (see Table 2). All types of permeants, from small hydrophobic compounds, such as salicylic acid, to highly hydrophilic compounds, such as vasopressin, to proteins, such as insulin, and even vaccines or …Author: Baris E. Polat, Douglas Hart, Robert Langer, Daniel Blankschtein
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4725305/
Ultrasound contrast agents for increased transdermal drug delivery Another interesting approach involves the use of HFS and ultrasound contrast agents (UCAs) in the coupling solution. UCAs are commonly used in contrast-enhanced US imaging of blood perfusion in organs, to measure the blood flow rate in the heart among many other applications [ 58 ].Author: Matthias A Oberli, Carl M Schoellhammer, Robert Langer, Daniel Blankschtein
https://www.sciencedirect.com/science/article/pii/S0169409X14000088
Transdermal drug delivery offers an attractive alternative to the conventional drug delivery methods of oral administration and injections. However, the stratum corneum serves as a barrier that limits the penetration of substances to the skin.Author: Aharon Azagury, Luai Khoury, Giora Enden, Joseph Kost
https://www.sciencedirect.com/science/article/pii/S1359644604031708
Application of ultrasound to the skin increases its permeability (sonophoresis) and enables the delivery of various substances into and through the skin. This review presents the main findings in the field of sonophoresis, namely transdermal drug delivery and transdermal monitoring.Author: Ilana Lavon, Joseph Kost
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2676802/
Ultrasound enhanced transdermal drug delivery offers advantages over traditional injection drug delivery methods which are invasive and painful. Currently few drugs, proteins or peptides have been successfully administered transdermally for clinical applications because of the low skin permeability to these relatively large molecules.Author: Nadine Barrie Smith
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2700785/
The opportunity for transdermal drug delivery is that cavitation bubbles concentrate the energy of ultrasound and thereby enable targeted effects at the site of bubble activity 30, 41. Because bubbles are more difficult to grow and oscillate within densely-packed tissue, cavitation preferentially occurs within the coupling medium (e.g., a hydrogel) between the ultrasound transducer and skin.Author: Mark R Prausnitz, Robert Langer
https://www.ncbi.nlm.nih.gov/pubmed/18997767
Transdermal drug delivery has made an important contribution to medical practice, but has yet to fully achieve its potential as an alternative to oral delivery and hypodermic injections. First-generation transdermal delivery systems have continued their steady increase in clinical use for delivery of small, lipophilic, low-dose drugs.Author: Mark R Prausnitz, Robert Langer
https://biomeddermatol.biomedcentral.com/articles/10.1186/s41702-020-0058-7
Transdermal delivery systems have been intensively studied over the past 2 decades, with the focus on overcoming the skin barrier for more effective application of pharmaceutical and cosmetic products. Although the cosmeceutical industry has made a substantial progress in the development and incorporation of new and effective actives in their products, the barrier function of the skin remains ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3635663/
Apr 22, 2013 · Ultrasound is an important local stimulus for triggering drug release at the target tissue. Ultrasound-responsive drug delivery systems (URDDS) have become an important research focus in targeted therapy. URDDS include many different formulations, such as microbubbles, nanobubbles, nanodroplets, liposomes, emulsions, and micelles.Author: Ying-Zheng Zhao, Li-Na Du, Cui-Tao Lu, Yi-Guang Jin, Shu-Ping Ge
https://mentoriafabioborges.com.br/pdf/2000%20-%20LONG%20LE%20-%20EFEITO%20COMBINADO%20DO%20ULTRA-SOM%20DE%20BAIXA%20FREQUÊNCIA%20E%20IONTOFORESE.pdf
Transdermal drug delivery offers several advantages over traditional drug delivery systems such as oral delivery and injection including elimination of first pass metabolism, minimization of pain, and possibility of sustained release of drugs (1). However, transdermal transport of molecules is slow due to the low permeability of stratum corneum ...
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