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https://www.researchgate.net/publication/6696184_Tumor_Physiology_and_Delivery_of_Nanopharmaceuticals
The use of this nanodrug delivery system to deliver DOX for treatment of tumor-bearing mice produced a much improved therapeutic efficacy in terms of tumor growth suppression …
https://www.ingentaconnect.com/content/ben/acamc/2006/00000006/00000006/art00002
We discuss here, the physiological role of solid tumors in delivery and transport of nanopharmaceutical products. The nature of tumors in terms of their unique anatomical structure and functions is also discussed. Finally, an overview of ways to overcome physiological barrier functions and exploit tumor pathogenesis for therapeutic gain is provided.
http://www.eurekaselect.com/openurl/content.php?genre=article&issn=1871-5206&volume=6&issue=6&spage=503
Keywords:Tumor vasculature, interstitial transport, vascular permeability, interstitial fluid pressure. Abstract: Over the past few decades significant advances have been made in the development of nanopharmaceuticals (including phospholipid and polymer-based therapeutics) against cancer. There is still, however, room for improvement.
http://www.eurekaselect.com/57994
Tumor Physiology and Delivery of Nanopharmaceuticals Author(s): Robert B. Campbell . Northeastern University,Bouve College of Health Sciences, Department of Pharmaceutical Sciences,Boston, MA 02115, USA.Author: Robert B. Campbell
https://www.omicsonline.org/anatomy/tumor-anatomy.php
Jun 01, 2014 · At each of these steps there are barriers, related to tumor anatomy and physiology, which hinder delivery of the drug throughout the entire tumor. Poor efficacy of promising therapeutics may be attributable to these barriers.
https://cancerres.aacrjournals.org/content/canres/58/7/1408.full.pdf
The Vasculature: Basis for the Unique Physiology of Solid Tumors. The underlying differences between the physiology of nor mal and tumor tissues stems from the tumor vasculature. This is composed of two types of vessels: the existing vessels in normal tissues into which the tumor has invaded; and tumor …Author: J. Martin Brown, Amato J. Giaccia
https://www.sciencedirect.com/topics/medicine-and-dentistry/tumor-physiology
4.1 Tumor Physiology can Promote or Inhibit Delivery The term cancer encompasses hundreds of complicated diseases with distinct presentations, available treatments, and prognoses. At the most basic level, cancers are characterized by aberrant and uncontrolled cell growth.
https://www.researchgate.net/publication/222090584_Nanopharmaceuticals_I_Nanocarrier_Systems_in_Drug_Delivery_Invited_Paper
Request PDF from the authors On Jan 1, 2011, Yun-Seok Rhee Heidi M. Mansour and others published Nanopharmaceuticals I: Nanocarrier Systems in Drug Delivery. Invited Paper Find, read and cite ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3445794/
Ideally, anti-cancer drug molecules should act specifically on target cancer cells and accumulate preferentially at target tissues in sufficient concentration [55, 56]. Therefore, improvement of delivery efficacy of anti-cancer drugs can enhance the selective cytotoxicity to tumor cells, and is essential to reducing side effects in the body.Author: K. K. Y. Wong, X. L. Liu
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2746980/
Sep 15, 2009 · The results of chemotherapy of the mouse bearing two ovarian carcinoma tumors inoculated in the right and left flank are presented in Figure 5. This mouse was treated by four systemic injections of the nanodroplet encapsulated PTX, nbGEN (20 mg/kg as PTX) given twice weekly; only one (the right) tumor was sonicated.Author: Natalya Y. Rapoport, Anne M. Kennedy, Jill E. Shea, Courtney L. Scaife, Kweon-Ho Nam
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