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https://science.sciencemag.org/content/296/5577/2404.full
Jun 28, 2002 · Tumor Regression by Targeted Gene Delivery to the Neovasculature. 1 Department of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA. 2 Lucas Magnetic Resonance Spectroscopy Research Center, Stanford School of Medicine, 1201 Welch Road, Stanford, CA 94305, USA.Author: John D. Hood, Mark Bednarski, Ricardo Frausto, Samira Guccione, Ralph A. Reisfeld, Rong Xiang, David...
https://www.ncbi.nlm.nih.gov/pubmed/12089446
Jun 28, 2002 · Efforts to influence the biology of blood vessels by gene delivery have been hampered by a lack of targeting vectors specific for endothelial cells in diseased tissues. Here we show that a cationic nanoparticle (NP) coupled to an integrin alphavbeta3-targeting ligand can deliver genes selectively to angiogenic blood vessels in tumor-bearing mice.Author: John D. Hood, Mark Bednarski, Ricardo Frausto, Samira Guccione, Ralph A. Reisfeld, Rong Xiang, David...
https://www.researchgate.net/publication/11286975_Tumor_Regression_by_Targeted_Gene_Delivery_to_the_Neovasculature
Efforts to influence the biology of blood vessels by gene delivery have been hampered by a lack of targeting vectors specific for endothelial cells in diseased tissues.
http://adsabs.harvard.edu/abs/2002Sci...296.2404H
The therapeutic efficacy of this approach was tested by generating NPs conjugated to a mutant Raf gene, ATP μ-Raf, which blocks endothelial signaling and angiogenesis in response to multiple growth factors. Systemic injection of the NP into mice resulted in apoptosis of the tumor-associated endothelium, ultimately leading to tumor cell apoptosis and sustained regression of established primary and metastatic tumors.
https://www.academia.edu/5138548/Tumor_Regression_by_Targeted_Gene_Delivery_to_the_Neovasculature
Tumor Regression by Targeted Gene Delivery to the Neovasculature
https://www.cell.com/trends/molecular-medicine/fulltext/S1471-4914(02)00004-7
The α v β 3 integrin is a potential pharmacological target for anti-angiogenic therapy. A recent report describes the use of α v β 3 -targeted nanoparticles to deliver a gene to tumour vasculature selectively. This resulted in substantial tumour regression in several experimental mouse tumour models.Author: Andrew R Reynolds, S Moein Moghimi, Kairbaan Hodivala-Dilke
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