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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4089357/
Brain tumors are inherently difficult to treat in large part due to the cellular blood-brain barriers (BBB) that limit the delivery of therapeutics to the tumor tissue from the systemic circulation. Virtually no large-molecules, including antibody-based ...Author: Ann-Marie Chacko, Chunsheng Li, Daniel A. Pryma, Steven Brem, George Coukos, Vladimir R. Muzykantov
https://www.sciencedirect.com/topics/medicine-and-dentistry/tumor-physiology
4.1 Tumor Physiology can Promote or Inhibit Delivery. The term cancer encompasses hundreds of complicated diseases with distinct presentations, available treatments, and prognoses. At the most basic level, cancers are characterized by aberrant and uncontrolled cell growth.
https://www.ncbi.nlm.nih.gov/pubmed/31828446
Dec 11, 2019 · Antibody-drug conjugates (ADCs) are cancer drugs composed of a humanized antibody linked to a cytotoxic payload, allowing preferential release of payload in cancer cells expressing the antibody-targeted antigen. Here, a systems pharmacology model is used to simulate ADC transport from blood to tumor tissue and ADC uptake by tumor cells.Author: Jackson K. Burton, Dean Bottino, Timothy W. Secomb
http://cancerres.aacrjournals.org/content/canres/50/3_Supplement/814s.full.pdf
of tumor-associated antigen expression alone has failed to explain the nonuniform uptake of antibodies. As a result, only in recent years have the peculiarities of tumor physiology been recognized as determinants of antibody distribution. Three physiological barriers responsible for theAuthor: Rakesh K. Jain
https://www.nature.com/articles/nbt1141
Sep 07, 2005 · Pretargeting strategies, which separate the two functions of antibody-based localization and delivery or generation of the toxic agent into two steps, also promise to afford superior tumor ...Author: Anna M Wu, Peter D Senter
https://www.ajronline.org/doi/full/10.2214/ajr.177.4.1770747
The molecule must be delivered to the target tissue in adequate quantities. Solid tumors have inherent, formidable barriers to the delivery of such agents. Therefore, tumor transport physiology will play a central role in the success or failure of new strategies for molecular imaging and imaging-guided therapy.Author: B. S. Kuszyk, F. M. Corl, F. N. Franano, D. A. Bluemke, L. V. Hofmann, B. J. Fortman, Elliot K Fishm...
https://journals.physiology.org/doi/full/10.1152/physiologyonline.2001.16.4.191
An abundance of tumor antigen in the perivascular region, a dense network of ECM components, and an elevated interstitial pressure further limit antibody diffusion to distant tumor cells. In fact, in patients, typically only 0.001–0.01% of the injected antibody dose accumulates localized per gram of solid tumor.Author: Cornelia Halin, Luciano Zardi, Dario Neri
https://mct.aacrjournals.org/content/18/11/2074
Nov 01, 2019 · Despite frequent overexpression of numerous growth factor receptors by pancreatic ductal adenocarcinomas (PDAC), such as EGFR, therapeutic antibodies have not proven effective. Desmoplasia, hypovascularity, and hypoperfusion create a functional drug delivery barrier that contributes to treatment resistance. Drug combinations that target tumor/stroma interactions could enhance tumor …Author: Jun Wang, Darren K.W. Chan, Arindam Sen, Wen Wee Ma, Robert M. Straubinger
https://www.sciencedirect.com/science/article/pii/B9780128139974000128
In rat brain tumors, nanoliposomal formulations of PTX demonstrated greater efficacy with sequential administrations and were more effective at lower doses applied more frequently. 90 A formulation of nanoliposomal irinotecan similarly increased tumor delivery of subsequently administered drugs such as DXR and 5-FU, and the mechanism was the ...Author: Tista Roy Chaudhuri, Robert M. Straubinger
https://cancerres.aacrjournals.org/content/80/6/1268
Mar 15, 2020 · Tumor histology images and whole-animal imaging (Supplementary Fig. S16) captured the overall fluorescent antibody distribution following intravenous delivery at the same doses as the efficacy study. Similar trends were seen for in vivo tumor distribution as those predicted by the computational model and demonstrated in the spheroid experiments.Author: Ian Nessler, Eshita Khera, Steven Vance, Anna Kopp, Qifeng Qiu, Thomas A. Keating, Adnan O. Abu-Yous...
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