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https://www.nature.com/articles/nature05901
Jun 17, 2007 · Taken together, our results suggest that RVG-9R peptide may enable transvascular delivery of siRNA to the central nervous system. The relatively modest (about 50%) knockdown obtained is comparable to that reported after prolonged infusion of siRNA in the central nervous system.Author: Priti Kumar, Haoquan Wu, Jodi L. McBride, Kyeong-Eun Jung, Moon Hee Kim, Beverly L. Davidson, Sang K...
https://www.cell.com/cms/10.1016/j.ymthe.2018.08.005/attachment/0adddc7c-d3d7-4371-9d46-a68f795a33ac/mmc1.pdf
transvascular delivery to the brain. PC-DHA-hsiRNAs (16 mg/kg) or saline were administered through the right carotid artery after pre-treatment with mannitol. A comprehensive diagnostic blood chemistry profile of 14 biochemical markers was analyzed 7 days post-injection using a VetScan 2.
https://www.ncbi.nlm.nih.gov/pubmed/17572664
Moved Permanently. The document has moved here.Author: Priti Kumar, Haoquan Wu, Jodi L. McBride, Kyeong-Eun Jung, Moon Hee Kim, Beverly L. Davidson, Sang K...
https://www.ncbi.nlm.nih.gov/pubmed/30143435
Nov 07, 2018 · Effective transvascular delivery of therapeutic oligonucleotides to the brain presents a major hurdle to the development of gene silencing technologies for treatment of genetically defined neurological disorders.Author: Bruno M.D.C. Godinho, Nils Henninger, James Bouley, Julia F. Alterman, Reka A. Haraszti, James W. Gi...
https://www.researchgate.net/publication/6263796_Transvascular_delivery_of_small_interfering_RNA_to_the_central_nervous_system
A major impediment in the treatment of neurological diseases is the presence of the blood-brain barrier, which precludes the entry of therapeutic molecules from blood to brain. Here we show that a short peptide derived from rabies virus glycoprotein (RVG) enables the transvascular delivery of small interfering RNA (siRNA) to the brain.
https://www.nature.com/articles/ncpneuro0596
Transvascular delivery of siRNA to the CNS mediated by RVG–9R results in a gene-silencing effect comparable to that of direct injection, with the effect declining at a similar rate.
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