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https://www.researchgate.net/publication/6263796_Transvascular_delivery_of_small_interfering_RNA_to_the_central_nervous_system
Transvascular delivery of small interfering RNA to the central nervous system. ... ena ble d si RNA uptak e by both cells, and RV-MAT-9R was una bl e to.
https://www.nature.com/articles/nrn2205
Aug 01, 2007 · Reporting in Nature, Kumar and colleagues have now developed a method to target small-interfering RNA (siRNA) to the CNS, providing a safe …Author: Alexandra Flemming
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6684241/
RNA interference is a relatively new tool used to silence specific genes in diverse biological systems. The development of this promising new technique for research and therapeutic use in studying and treating neurological diseases has been hampered by the lack of an efficient way to deliver siRNA transvascularly across the blood-brain barrier (BBB) to the central nervous system (CNS).
http://www.nature.com/nature/journal/v448/n7149/fig_tab/nature05901_F2.html
Jun 17, 2007 · Figure 3: RVG-9R enables transvascular delivery of siRNA to the central nervous system. a , Mice were injected intravenously with FITC-siRNA/peptide complexes, and …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2698461/
Most pre-clinical and clinical studies on delivery of RNAi to the CNS have utilized invasive, intra-cerebral delivery of RNA to the targeted tissue. Thus, methods need to be developed to facilitate delivery of therapeutically significant quantities of RNA to the CNS via the systemic route, and to elicit clinically significant RNAi effects ...Author: Saroj P Mathupala
https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(18)30376-9
Godinho et al. demonstrate the utility of transient blood-brain barrier (BBB) disruption using hyperosmolar mannitol as a delivery strategy for fully modified lipid-conjugated hydrophobic siRNAs (hsiRNAs). Phosphocholine-docosahexanoic acid (PC-DHA)-conjugated hsiRNAs broadly distribute in the brain after BBB disruption, enabling potent gene silencing without major neurotoxicity.Author: Bruno M.D.C. Godinho, Nils Henninger, James Bouley, Julia F. Alterman, Reka A. Haraszti, James W. Gi...
https://www.jove.com/video/54106/delivery-therapeutic-sirna-to-cns-using-cationic-anionic
Delivery of Therapeutic siRNA to the CNS Using Cationic and Anionic Liposomes Heather R. Bender 1 , Sarah Kane 1 , Mark D. Zabel 1 1 Department of Microbiology, Immunology, and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State UniversityAuthor: Heather R. Bender, Sarah Kane, Mark D. Zabel
https://www.sciencedirect.com/science/article/pii/S1525001618303769
After transvascular delivery, PC-DHA-hsiRNAs silenced their target mRNA with high specificity and potency, to a similar extent to what was observed in previous dose-response studies in the brain.6, 7 Although transvascular delivery of PC-DHA-hsiRNA reduced Htt mRNA in multiple regions of the brain, a significant reduction of HTT protein was ...Author: Bruno M.D.C. Godinho, Nils Henninger, James Bouley, Julia F. Alterman, Reka A. Haraszti, James W. Gi...
https://www.cell.com/molecular-therapy-family/molecular-therapy/pdfExtended/S1525-0016(18)30376-9
Transvascular Delivery of Hydrophobically Modified siRNAs: Gene Silencing in the Rat ... nucleotides achieves limited distribution to the CNS (delivery is mostly restricted to the choroid plexus).6 Similarly, other therapeutic ... RNA Therapeutics Institute, University of Massachusetts Medical School, 368 Plantation Street, AS4-1013, Worcester, MA
https://www.researchgate.net/publication/305635690_Delivery_of_Therapeutic_siRNA_to_the_CNS_Using_Cationic_and_Anionic_Liposomes
We developed a therapeutic delivery system consisting of small interfering RNA (siRNA) complexed to liposomes and addressed to the central nervous system using a targeting peptide derived from ...
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