Transvascular Delivery

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Transvascular delivery of small interfering RNA to the ...

    https://www.nature.com/articles/nature05901
    Jun 17, 2007 · Here we show that a short peptide derived from rabies virus glycoprotein (RVG) enables the transvascular delivery of small interfering RNA (siRNA) to the brain. This 29-amino-acid peptide ...Author: Priti Kumar, Haoquan Wu, Jodi L. McBride, Kyeong-Eun Jung, Moon Hee Kim, Beverly L. Davidson, Sang K...

Transvascular drug delivery in solid tumors - ScienceDirect

    https://www.sciencedirect.com/science/article/pii/S1053429698800428
    Transvascular Drug Delivery in Solid Tumors f arz Yua12 The microvessel wall is a barrier for the delivery of various therapeutic agents to tumor cells. Tumor mi- crovessels are, in general, more permeable to macromol- ecules than normal vessels.Author: Fan Yuan

Transvascular dictionary definition transvascular defined

    https://www.yourdictionary.com/transvascular
    transvascular definition: Adjective (not comparable) 1. Across the wall of a blood vessel (similar vessel)...

Transvascular Delivery of Hydrophobically Modified siRNAs ...

    https://www.ncbi.nlm.nih.gov/pubmed/30143435
    Nov 07, 2018 · Effective transvascular delivery of therapeutic oligonucleotides to the brain presents a major hurdle to the development of gene silencing technologies for treatment of genetically defined neurological disorders. Distribution to the brain after systemic administrations is hampered by the low permeability of the blood-brain barrier (BBB) and the ...Author: Bruno M.D.C. Godinho, Nils Henninger, James Bouley, Julia F. Alterman, Reka A. Haraszti, James W. Gi...

Highly site-selective transvascular drug delivery by the ...

    https://www.sciencedirect.com/science/article/pii/S0168365914005422
    We have been investigating the use of nanosecond pulsed laser-induced photomechanical waves (PMWs) for gene delivery in vivo, , , , , , and we found that PMWs can increase the permeability of blood vessels . In this study, we investigated characteristics of …Author: Shunichi Sato, Ken Yoshida, Satoko Kawauchi, Kazue Hosoe, Yusuke Akutsu, Norihiro Fujimoto, Hiroshi ...

Transvascular delivery of small interfering RNA to the ...

    https://ohsu.pure.elsevier.com/en/publications/transvascular-delivery-of-small-interfering-rna-to-the-central-ne-2
    Jul 07, 2007 · A major impediment in the treatment of neurological diseases is the presence of the blood-brain barrier, which precludes the entry of therapeutic molecules from blood to brain. Here we show that a short peptide derived from rabies virus glycoprotein (RVG) enables the transvascular delivery of small interfering RNA (siRNA) to the brain.Author: Priti Kumar, Haoquan Wu, Jodi L. McBride, Kyeong-Eun Jung, Moon Hee Kim, Beverly L. Davidson, Sang K...

Transvascular — ExploraMed

    https://www.exploramed.com/transvascular
    Transvascular pioneered the development of the CrossPoint® TransAccess® Catheter System, a platform technology that incorporates phased array intravascular ultrasound imaging and a proprietary needle delivery system.. This combination of technologies can facilitate a variety of current and potential therapies throughout the body. Transvascular was acquired in 2003 by Medtronic, Inc.

(PDF) Transvascular delivery of small interfering RNA to ...

    https://www.researchgate.net/publication/6263796_Transvascular_delivery_of_small_interfering_RNA_to_the_central_nervous_system
    Transvascular delivery of small interfering RNA to the central nervous system Article (PDF Available) in Nature 448(7149):39-43 · August 2007 with 460 Reads How we measure 'reads'

Supplemental Information Transvascular Delivery of ...

    https://www.cell.com/cms/10.1016/j.ymthe.2018.08.005/attachment/0adddc7c-d3d7-4371-9d46-a68f795a33ac/mmc1.pdf
    Supplemental Information Figure S2. Unconjugated siRNAs present limited retention in the rat brain after transvascular delivery. Cy3-labelled siRNAs 37 mg/kg were injected through the right carotid artery preceded by mannitol.

Delivery of small-interfering RNA (siRNA) to the brain

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2698461/
    Two fundamental difficulties in the delivery of drugs to treat central nervous system (CNS) diseases are the systemic delivery of therapeutics across the bloodbrain-barrier (BBB), and the targeting of drugs to specific tissues or cells within the brain. ...Author: Saroj P Mathupala

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