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Transungual Drug Delivery: An Overview Vivek B. Rajendra, Anjana Baro, Abha Kumari, Dinesh L. Dhamecha, ABSTRACT The body normally hosts a variety of microorganisms, including bacteria and fungi. Some of these are useful to the body and others may cause infections. Fungi can live on the dead tissues of the hairs, nails.File Size: 141KB
https://www.ncbi.nlm.nih.gov/pubmed/22149347
Ungual and transungual drug delivery. Shivakumar HN(1), Juluri A, Desai BG, Murthy SN. Author information: (1)KLE University's College of Pharmacy, Bangalore, India. Topical therapy is desirable in treatment of nail diseases like onychomycosis (fungal infection of nail) and psoriasis.Author: H. N. Shivakumar, Abhishek Juluri, B. G. Desai, S. Narasimha Murthy
https://onlinelibrary.wiley.com/doi/full/10.1111/ics.12142
May 29, 2014 · These factors affect drug uptake and permeation through the nail. Formulations like nail lacquers which mimic cosmetic varnish and colloidal carriers along with nail substitutes that can be utilized for transungual delivery have also been discussed.Author: P. Thatai, B. Sapra
https://www.ncbi.nlm.nih.gov/pubmed/25607707
BACKGROUND: Effective transungual delivery of topical antifungal agents in onychomycosis has been hampered by poor nail permeation. To be effective they must have antifungal efficacy, and effectively permeate through the dense keratinized nail plate to the site of infection in the nail bed and nail matrix.Author: Sakamoto M, Sugimoto N, Kawabata H, Yamakawa E, Kodera N, Pillai R, Tatsumi Y
https://onlinelibrary.wiley.com/doi/pdf/10.1111/ics.12142
Transungual delivery P. Thatai and B. Sapra. are structurally similar, the difference lies only in their size. More-over, the structure of equine foot is more or less same as that of cattle but with some differences like the presence of V-shaped cleftAuthor: P. Thatai, B. Sapra
https://www.researchgate.net/publication/262692308_Transungual_delivery_Deliberations_and_Creeds
Transungual nail penetrance has traditionally been considered to be the only route of delivery for topical antifungals in onychomycosis. Subungual penetrance may be an alternate route of delivery.
https://www.hindawi.com/journals/scientifica/2016/1387936/
Transungual Drug Delivery Transungual drug delivery is defined as system which is related to drug transport across the nail to gain targeted drug delivery in order to treat nail diseases. In the term transungual, “Trans” signifies “through” and “unguis” signifies “nails” [ 10 ].Author: Nida Akhtar, Hemlata Sharma, Kamla Pathak
https://www.sciencedirect.com/science/article/pii/S230750231630056X
Therefore topical delivery through nails also known as transungual drug delivery system came into picture. But transungual delivery had its own challenges. Nail plate is made up of cross linked keratin linkages which impart extensive bonding responsible for hardness of the nail plate.Author: Pradnya Palekar Shanbhag, Urvi Jani
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