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https://www.researchgate.net/publication/228835145_Insulin_drug_delivery_systems_A_review
Insulin delivery systems that are currently available for the administration of insulin include syringes, insulin infusion pumps, jet injectors and pens.
https://pdfs.semanticscholar.org/ee33/6c986385179554218a14f3928c24ddf0fbfa.pdf
pancreas with closed- loop system, transdermal insulin, and buccal, oral, pulmonary, nasal, ocular and rectal routes are the newer methods explored [2]. 2. MODERN INSULIN DELIVERY SYSTEMS 2.1 Insulin Pen Injectors These are the one of major advances in the insulin delivery that has made self-injection easier and convenient.
http://schererclin.com/documents/scherer_delivery_print.pdf
availability of a variety of insulin delivery systems enhances patient convenience and flexibility, the myriad of choices can be confusing both to patients and to healthcare providers. This monograph summarizes the currently available and investigational insulin delivery devices and methods of delivery.
https://www.semanticscholar.org/paper/Various-Emerging-Trends-in-Insulin-Drug-Delivery-Yasmeen-Mamatha/7a3c6b4052aa65bb5542325e7798b5eb90e92736
Insulin delivery systems that are currently available include syringes, infusion pumps, jet injectors and pens. The tedious part for the type 1 diabetes patients is to tolerate needle after needle injections while undergoing treatment for both glucose measurement and to deliver insulin.
https://www.researchgate.net/publication/40440757_Advances_in_insulin_drug_delivery_systems
Advances in insulin drug delivery systems Anil Pethe* 1 , Bharath Konda 1 , Trinath Mustyala 1 , Viral Shah 1 * 1 Department of Pharmaceutics, School of Pharmacy and Technology Management, NMIMS ...
https://www.webmd.com/diabetes/features/insulin-delivery
The drug peaks in the blood in about 15-20 minutes, researchers say, and clears the body in 2-3 hours. Needle-free. Users place a dose of insulin, in powder form, into a small, whistle-sized inhaler.
http://ijpsnonline.com/Issues/1057_full.pdf
disadvantages by oral delivery of insulin. The oral route is considered to be the most acceptable and convenient route of drug administration for chronic therapy. Due to knowledge explosion in the biotechnology industry, extensive investigations are being conducted to achieve successful control of blood glucose by the oral delivery system.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4787057/
Therefore, the first step in making an artificial pancreas (closed-loop system) is to suspend insulin delivery once CGM glucose is at a low threshold (often 70 or 60 mg/dl) to reduce nocturnal hypoglycemia. The threshold suspends (TS) system suspends the delivery of insulin for up to 2 h if a patient does not take action with a low glucose alarm.
https://science.sciencemag.org/content/363/6427/611.full
Feb 08, 2019 · Motivated by patient and health care professional preference for oral delivery, research on ingestible biomacromolecule formulations began in 1922, the same year as the first insulin injection ( 1, 2 ). This initial study, along with others that followed, …Author: Alex Abramson, Ester Caffarel-Salvador, Minsoo Khang, David Dellal, David Silverstein, Yuan Gao, Mor...
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