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https://experts.umn.edu/en/publications/sustained-transscleral-drug-delivery
Transscleral delivery is an emerging, high-potential method for delivering drugs to the posterior eye. If successful, it could offer non-invasiveness comparable to drops and delivery efficiency comparable to intravitreal injection.Author: Victor H Barocas, Ram K Balachandran
https://www.ncbi.nlm.nih.gov/pubmed/12062532
In vitro and in vivo studies suggest that the transscleral route may offer a means to achieve the goal of sustained, targeted drug delivery to the posterior segment. Potentially therapeutic concentrations of macromolecules with retention of bioactivity can be attained in the choroid and retina via minimally invasive transscleral delivery. PMID:Author: Jayakrishna Ambati, Jayakrishna Ambati, Anthony P Adamis, Anthony P Adamis
https://www.sciencedirect.com/science/article/pii/S0169409X01001934
Oct 31, 2001 · The utilization of some type of sustained-release delivery system would thus appear to be necessary for the successful utilization of transscleral drug delivery. An ideal sustained-release transscleral delivery system would provide controlled, long-term drug release, specific scleral site delivery, and prolong drug–sclera contact time.Author: Dayle H Geroski, Henry F Edelhauser
https://www.ncbi.nlm.nih.gov/pubmed/17069929
Nov 15, 2006 · The existing simulation models related to the transscleral drug delivery are reviewed and future directions for the model development are discussed. In addition, a new simulation model for the transscleral drug delivery based on permeability data is introduced.Author: Veli-Pekka Ranta, Arto Urtti
https://drum.lib.umd.edu/bitstream/handle/1903/3609/umi-umd-3457.pdf;sequence=1
the barriers to transscleral drug delivery was performed in a rabbit model, and the model demonstrated that the conjunctival lymphatic and blood vessels may be a predominant barrier to the delivery of triamcinolone acetonide to the vitreous. In Part 2, the pharmacokinetics of a cyclosporine episcleral implant for high-risk penetrating
https://www.sciencedirect.com/science/article/pii/S0928493119307143
3.1. Drug quantification, stability, and ability of transscleral diffusion. Relatively long drug stability is required for the proposed implant to be therapeutically efficient. The drug must be loaded into the hydrogel implant via hydrogel immersion in the drug solution. During subsequent implant application, the drug must be released from the ...Author: Ana-Irina Cocarta, Radka Hobzova, Jakub Sirc, Tereza Cerna, Jan Hrabeta, Karel Svojgr, Pavel Pochop,...
https://www.researchgate.net/publication/333412466_Hydrogel_implants_for_transscleral_drug_delivery_for_retinoblastoma_treatment
local transscleral drug delivery in the treatment of Rb. The further. challenge remains the developing of the methodology for fabrication of.
https://www.deepdyve.com/lp/elsevier/transscleral-drug-delivery-to-the-retina-and-choroid-9fWA7o4YaO
Mar 01, 2002 · Transscleral drug delivery to the retina and choroid Transscleral drug delivery to the retina and choroid Ambati, Jayakrishna; Adamis, Anthony P 2002-03-01 00:00:00 Rapid advances in the molecular pathogenesis of retinal and choroidal disorders have highlighted the urgent need for innovative drug delivery modalities to the loci of pathology.
https://www.tandfonline.com/doi/abs/10.1080/17425247.2018.1406918
Nov 30, 2017 · ABSTRACTIntroduction: The sclera is considered the ‘static barrier,’ a main barrier for transscleral drug delivery. The characterization of passive and iontophoretic transport across the sclera in vitro is the first step toward our ability to predict transscleral drug delivery. Although previous studies have investigated this topic, the quantitative structure permeation relationships (QSPR ...Author: S. Kevin Li, Jinsong Hao
https://link.springer.com/chapter/10.1007/978-1-4419-9920-7_7
Jun 20, 2011 · Cruysberg LPJ, Nuyts RMMA, Gilbert JA, Geroski DH, Hendricks F, Edelhauser HF (2005) In vitro sustained human transscleral drug delivery of fluorescein labeled dexamethasone and methotrexate with fibrin sealant. Curr Eye Res 30:653–660 PubMed CrossRef Google ScholarAuthor: Dayle H. Geroski, Henry F. Edelhauser
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