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https://www.sciencedirect.com/science/article/pii/S0014483508003539
Transscleral iontophoretic and intravitreal delivery of a macromolecule: Study of ocular distribution in vivo and postmortem with MRI 1. Introduction. Previous MRI studies using manganese ion... 2. Experimental section. Galbumin™ (25 mg/ml) was purchased from BioPAL, Inc. (Worcester, MA). 3. ...Author: Sarah A. Molokhia, Eun Kee Jeong, William I. Higuchi, S. Kevin Li
https://www.future-science.com/doi/10.4155/tde.11.104
Trans-scleral delivery of macromolecules. Abstract. Non-invasive drug delivery to the posterior segment of the eye represents an important unmet medical need, and trans-scleral delivery could be an interesting solution.Author: Silvia Pescina, Patrizia Santi, Giulio Ferrari, Sara Nicoli
https://moh-it.pure.elsevier.com/en/publications/trans-scleral-delivery-of-macromolecules
title = "Trans-scleral delivery of macromolecules", abstract = "Non-invasive drug delivery to the posterior segment of the eye represents an important unmet medical need, and trans-scleral delivery could be an interesting solution.Author: Silvia Pescina, Patrizia Santi, Giulio Ferrari, Sara Nicoli
https://www.researchgate.net/publication/229555009_Trans-scleral_delivery_of_macromolecules
The distribution and clearance of macromolecules in ocular delivery are not well understood. It has been hypothesized that iontophoresis can enhance transscleral delivery of macromolecules.
https://www.ncbi.nlm.nih.gov/pubmed/19000673
It has been hypothesized that iontophoresis can enhance transscleral delivery of macromolecules. The objective of this study was to investigate the ocular distribution of a macromolecule after transscleral iontophoretic delivery and intravitreal injection in vivo using nuclear magnetic resonance imaging (MRI) and to compare these results.Author: Sarah A. Molokhia, Eun Kee Jeong, William I. Higuchi, S. Kevin Li
http://europepmc.org/articles/PMC2723719
Mar 01, 2009 · Most transscleral iontophoresis studies have been focused on the delivery of small molecules with only a few studies on macromolecules. Particularly, the barriers, distribution, and penetration of macromolecules into the eye are not well understood.
https://www.ncbi.nlm.nih.gov/pubmed/23722390
Jun 26, 2013 · Ultrasound-mediated transscleral delivery of macromolecules to the posterior segment of rabbit eye in vivo. Suen WL(1), Wong HS, Yu Y, Lau LC, Lo AC, Chau Y. Author information: (1)Department of Chemical and Biomolecular Engineering, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.Author: Wai-Leung Langston Suen, Hoi Sang Wong, Yu Yu, Laurence Chi Ming Lau, Amy Cheuk-Yin Lo, Ying Chau
https://www.researchgate.net/publication/236976965_Ultrasound-Mediated_Transscleral_Delivery_of_Macromolecules_to_the_Posterior_Segment_of_Rabbit_Eye_In_Vivo
Solution of fluorescent dextran (70 kDa) was placed above sclera during and after ultrasound application to assess transscleral transport of macromolecules. Amount of dextran delivered to vitreous...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142116/
Sep 28, 2014 · Intrascleral drug delivery has been explored as a possible delivery route to the back of the eye [39, 95–97]. The sclera is permeable to many drugs, including macromolecules (Table 1), and can potentially act as a drug reservoir for extended-release delivery [98, 99].Author: Yoo Chun Kim, Bryce Chiang, Xianggen Wu, Xianggen Wu, Mark R. Prausnitz
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