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https://www.sciencedirect.com/science/article/pii/S0169409X01001934
Oct 31, 2001 · The study found that transscleral delivery of anti-ICAM-1 antibody inhibited MPO activity by 80% in the choroid and by 70% in the retina compared to eyes that received control antibody. Additionally, no significant systemic absorption occurred with transscleral delivery.Author: Dayle H Geroski, Henry F Edelhauser
https://pubs.acs.org/doi/10.1021/mp2005164
Transscleral retinal delivery of celecoxib, an anti-inflammatory and anti-VEGF agent, is restricted by its poor solubility and binding to the melanin pigment in choroid-RPE. The purpose of this study was to develop soluble prodrugs of celecoxib with reduced pigment binding and enhanced retinal delivery. Three hydrophilic amide prodrugs of celecoxib, celecoxib succinamidic acid (CSA), celecoxib ...Author: Pradip Malik, Rajendra S. Kadam, Narayan P. S. Cheruvu, Uday B. Kompella
https://www.sciencedirect.com/science/article/pii/S0378517319304922
1. Introduction. Ocular drug delivery is a challenging problem, because of the specific environment that exists in the eye (Nayak and Misra, 2018).Successful treatments of retinal diseases, such as age-related macular disease (AMD), require effective concentrations of the drug to be maintained during long periods within the target site (Ding et al., 2009).Author: Nobuhiro Nagai, Zhaleh Kashkouli Nezhad, Reiko Daigaku, Saaya Saijo, Yuanhui Song, Keiko Terata, Aya...
https://www.ncbi.nlm.nih.gov/pubmed/17069929
Nov 15, 2006 · In this review we investigate the pharmacokinetic aspects of transscleral drug delivery into the posterior eye with emphasis on pharmacokinetic modeling. The existing simulation models related to the transscleral drug delivery are reviewed and future directions for …Author: Veli-Pekka Ranta, Arto Urtti
https://experts.umn.edu/en/publications/sustained-transscleral-drug-delivery
Transscleral delivery is an emerging, high-potential method for delivering drugs to the posterior eye. If successful, it could offer non-invasiveness comparable to drops and delivery efficiency comparable to intravitreal injection.Author: Victor H Barocas, Ram K Balachandran
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7005511/
Mar 13, 2020 · Experimental Design and In Vivo GFP Transgene Expression in Rhesus Macaque Eyes after Suprachoroidal Injection of AAV8 (A) Diagram of a primate eye showing different modes of AAV delivery, including intravitreal, subretinal (transretinal), and suprachoroidal or subretinal injections using transscleral microneedles.Author: Glenn Yiu, Sook Hyun Chung, Iris N. Mollhoff, Uyen Tu Nguyen, Sara M. Thomasy, Jesse Yoo, Donna Tara...
https://www.iridex.com/PhysicianEducation/Glaucoma/TSCPCG-Probe.aspx
Placement. Hold the G-Probe ® parallel to the visual axis with the shorter edge of the footplate firmly between the anterior border and the middle of the limbus. Laser delivery is transscleral. Application. Successive applications are spaced one-half the width of the G-Probe footplate apart by aligning a side of the probe over the indented center of the adjacent application.
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