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Learn how BMoGen is utilizing their unique expertise to provide gene editing services including fee-for-service and non-viral transposon based gene delivery platforms that address complex gene delivery and gene editing enabling scientists and bio-therapeutics companies to create life …
https://transposagenbio.com/
Transposagen was founded in 2003 to commercialize early gene editing technology. Since then, Transposagen has merged with Hera BioLabs and has significantly increased its scientific offerings to include a suite of gene editing technologies and services that address the research needs of both academic and drug discovery investigators.
https://www.liebertpub.com/doi/full/10.1089/hum.2017.128
Nov 01, 2017 · Typically, for liver-directed gene delivery, transposon and transposase constructs were administered by hydrodynamic (HD) injection that involves rapid delivery of large volumes of DNA solutions. 138 HD transfection of transposons resulted in sustained gene expression in liver and kidney. 59,62,139–142 In the absence of an active transposase, expression declined, perhaps due, …Author: TipaneeJaitip, VandenDriesscheThierry, K ChuahMarinee
https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(18)30019-4
Apr 04, 2018 · The Sleeping Beauty (SB) transposon system is a non-viral gene delivery platform that combines simplicity, inexpensive manufacture, and favorable safety features in …Author: Marta Holstein, Cristina Mesa-Nuñez, Csaba Miskey, Elena Almarza, Valentina Poletti, Marco Schmeer, ...
https://systembio.com/applications/gene-delivery/
Exosome Engineering—use exosomes as a non-viral method for gene delivery; Syn2Clone Custom Constructs—keep your hands off your pipettes with this service where you simply email us your gene sequence. We synthesize the gene and clone it into the SBI construct of your choice, all for little more than the cost of the empty vector.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2867038/
In cell culture systems ex vivo, transposon delivery can be achieved by transfection of plasmid DNA harboring the transposons or, alternatively, by mobilizing a single transposon, which has been placed in the genome by gene targeting or a prior transposition event.Author: Zoltán Ivics, Meng Amy Li, Lajos Mátés, Jef D. Boeke, Andras Nagy, Allan Bradley, Zsuzsanna Izsvák, ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3095056/
Apr 15, 2011 · Over the past decade, the Sleeping Beauty (SB) transposon system has been developed as the leading non-viral vector for gene therapy. This vector combines the advantages of viruses and naked DNA. Here we review progress over the last 2 years in vector design, methods of delivery and safety that have supported its use in the clinic.Author: Elena L. Aronovich, R. Scott McIvor, Perry B. Hackett
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