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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479283/
Essential to iron homeostasis is the transport of iron by the bilobal protein human serum transferrin (hTF). Each lobe (N- and C-lobe) of hTF forms a deep cleft which binds a single Fe 3+.Iron-bearing hTF in the blood binds tightly to the specific transferrin receptor (TFR), a homodimeric transmembrane protein.Author: Ashley N. Luck, Ashley N. Luck, Anne B. Mason
https://www.ncbi.nlm.nih.gov/pubmed/23046645
Transferrin-mediated cellular iron delivery. Luck AN(1), Mason AB. Author information: (1)Department of Biochemistry, University of Vermont, College of Medicine, Burlington, VT, USA. Essential to iron homeostasis is the transport of iron by the bilobal protein human serum transferrin (hTF).Author: Ashley N. Luck, Ashley N. Luck, Anne B. Mason
https://www.sciencedirect.com/science/article/pii/B978012394390300001X
Essential to iron homeostasis is the transport of iron by the bilobal protein human serum transferrin (hTF). Each lobe (N- and C-lobe) of hTF forms a deep cleft which binds a single Fe 3+.Iron-bearing hTF in the blood binds tightly to the specific transferrin receptor (TFR), a homodimeric transmembrane protein.Author: Ashley N. Luck, Ashley N. Luck, Anne B. Mason
https://www.researchgate.net/publication/232224696_Transferrin-Mediated_Cellular_Iron_Delivery
Transferrin-Mediated Cellular Iron Delivery. ... Such conjugates have demonstrated enhanced cellular uptake via transferrin-mediated mechanisms and increased selective cytotoxicity in a number of ...
https://bmcbiotechnol.biomedcentral.com/articles/10.1186/1472-6750-12-92
Nov 30, 2012 · Transferrin (TF) plays a critical physiological role in cellular iron delivery via the transferrin receptor (TFR)-mediated endocytosis pathway in nearly all eukaryotic organisms. Human serum TF (hTF) is extensively used as an iron-delivery vehicle in various mammalian cell cultures for production of therapeutic proteins, and is also being explored for use as a drug carrier to treat a …Author: Deshui Zhang, Hsin-Fang Lee, Steven C Pettit, Jennica L Zaro, Ning Huang, Wei-Chiang Shen
http://pharmrev.aspetjournals.org/content/54/4/561
Dec 01, 2002 · The membrane transferrin receptor-mediated endocytosis or internalization of the complex of transferrin bound iron and the transferrin receptor is the major route of cellular iron uptake. This efficient cellular uptake pathway has been exploited for the site-specific delivery not only of anticancer drugs and proteins, but also of therapeutic genes into proliferating malignant cells that ...Author: Zhong Ming Qian, Hongyan Li, Hongzhe Sun, Kwokping Ho
https://link.springer.com/article/10.1007/s00232-014-9637-0
Feb 27, 2014 · Current cancer management strategies fail to adequately treat malignancies with multivariable dose-restricting factors such as systemic toxicity and multi-drug resistance limiting therapeutic benefit, quality of life and complete long-term remission rates. The targeted delivery of a therapeutic compound aims to enhance its circulation and cellular uptake, decrease systemic toxicity …Author: Stephanie Tortorella, Tom C. Karagiannis
https://www.sciencedirect.com/science/article/pii/S0002962915368208
Supported by NIH Grant AM-30142, to Mehdi Tavassoli. Review Review: Transferrin-Mediated Cellular Iron Uptake Seiji Irie, MD Mehdi Tavassoli, MD * Veterans Administration Medical Center and the University of Mississippi School of Medicine, Jackson, Mississippi Veterans Administration Medical Center and the University of Mississippi School of Medicine Jackson Mississippi * V.A. Medical Center ...Author: Seiji Irie, Mehdi Tavassoli
https://www.researchgate.net/publication/11037116_Targeted_Drug_Delivery_via_the_Transferrin_Receptor-Mediated_Endocytosis_Pathway
The membrane transferrin receptor-mediated endocytosis or internalization of the complex of transferrin bound iron and the transferrin receptor is the major route of cellular iron uptake.
https://pubs.acs.org/doi/abs/10.1021/bc049775d
Apr 12, 2005 · Targeted drug delivery is an important research area in specific therapy. Transferrin-conjugated nanoparticles are an attractive formulation as a vehicle for specific cellular uptake and targeted drug delivery. In this report, atomic force microscopy imaging was used to visualize the process of cellular uptake of transferrin-coupled gold nanoparticles on the surfaces of live cells for the ...Author: Pei-Hui Yang, Xuesong Sun, Jen-Fu Chiu, Hongzhe Sun, Qing-Yu He
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