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https://www.ncbi.nlm.nih.gov/pubmed/11933019
Apart from iron, many other metal ions of therapeutic and diagnostic interests can also bind to transferrin at the iron sites and their transferrin complexes can be recognized by many cells. Therefore, transferrin has been thought as a "delivery system" for many beneficial and harmful metal ions into the cells.Author: Jon E. Chatterton, Abbot F. Clark
http://onlinelibrary.wiley.com/doi/10.1002/med.10008/abstract
Mar 26, 2002 · Therefore, transferrin has been thought as a “delivery system” for many beneficial and harmful metal ions into the cells. Transferrin has also be widely applied as a targeting ligand in the active targeting of anticancer agents, proteins, and genes to primary proliferating malignant cells that overexpress transferrin receptors.
https://www.sciencedirect.com/science/article/pii/S0939641108003378
Membrane transferrin receptor-mediated endocytosis is an efficient cellular uptake pathway for drug delivery of anticancer drugs . The transferrin receptor (TfR) is over-expressed in many tumors and has been widely studied.Author: Karsten Ulbrich, Telli Hekmatara, Elisabeth Herbert, Jörg Kreuter
http://pharmrev.aspetjournals.org/content/54/4/561
Dec 01, 2002 · The membrane transferrin receptor-mediated endocytosis or internalization of the complex of transferrin bound iron and the transferrin receptor is the major route of cellular iron uptake. This efficient cellular uptake pathway has been exploited for the site-specific delivery not only of anticancer drugs and proteins, but also of therapeutic genes into proliferating malignant cells that ...Author: Zhong Ming Qian, Hongyan Li, Hongzhe Sun, Kwokping Ho
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3521190/
Nov 30, 2012 · Qian ZM, Li H, Sun H, Ho K. Targeted drug delivery via the transferrin receptor-mediated endocytosis pathway. Pharmacol Rev. 2002; 54:561–587. doi: 10.1124/pr.54.4.561. Soni V, Jain SK, Kohli DV. Potential of transferrin and transferrin conjugates of liposomes in drug delivery and targeting. Am J Drug Deliv.Author: Deshui Zhang, Hsin-Fang Lee, Steven C Pettit, Jennica L Zaro, Ning Huang, Wei-Chiang Shen
https://www.researchgate.net/profile/Hongzhe_Sun/publication/11037116_Targeted_Drug_Delivery_via_the_Transferrin_Receptor-Mediated_Endocytosis_Pathway/links/00b4951936ce762b2a000000/Targeted-Drug-Delivery-via-the-Transferrin-Receptor-Mediated-Endocytosis-Pathway.pdf
Drug delivery via the transferrin receptormediated endocytosis pathway Qing Xia 1 , XiuWei Yang 2 , XiaoDa Yang 1,2* , ZhongMing Qian 3 , Kui Wang 1,2 1.
https://link.springer.com/article/10.1007/s13346-018-0552-2
Jun 18, 2018 · Therefore, targeting of TfR-mediated delivery could counteract drug delivery issues in GBM and create a delivery system that could cross the BBB effectively to utilize ligand-conjugated drug complexes through receptor-mediated transcytosis.Author: Hira Choudhury, Manisha Pandey, Pei Xin Chin, Yee Lin Phang, Jeng Yuen Cheah, Shu Chien Ooi, Kit Kay...
https://www.sciencedirect.com/topics/medicine-and-dentistry/transferrin
It has been reported that TfR are expressed in duodenal epithelial cells (Pietrangelo et al., 1992) and are responsible for receptor-mediated endocytosis for absorption of TfR-targeted drug delivery systems (Du et al., 2013). This warrants the potential of transferrin as …
https://www.researchgate.net/publication/11432693_Li_H_Qian_ZMTransferrintransferrin_receptor-mediated_drug_delivery_Med_Res_Rev_223_225-250
To improve the efficacy and selectivity, the transferrin (Trans) receptor mediated endocytosis can be utilized for drug delivery system design, as transferrin receptors are expressed on the blood ...
https://bmcbiotechnol.biomedcentral.com/articles/10.1186/1472-6750-12-92
Nov 30, 2012 · Transferrin (TF) plays a critical physiological role in cellular iron delivery via the transferrin receptor (TFR)-mediated endocytosis pathway in nearly all eukaryotic organisms. Human serum TF (hTF) is extensively used as an iron-delivery vehicle in various mammalian cell cultures for production of therapeutic proteins, and is also being explored for use as a drug carrier to treat a …Author: Deshui Zhang, Hsin-Fang Lee, Steven C Pettit, Jennica L Zaro, Ning Huang, Wei-Chiang Shen
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