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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500658/
Significant increases in drug accumulation in the tumor tissue by the EPR effect can reach 10-fold or higher concentration with drug-loaded nanoparticles compared to free drug . Active targeting requires the use of targeting moieties, such as antibodies or receptor ligands, conjugated to the surface of the nanocarrier systems for their delivery enhancement.Author: Tracy R. Daniels, Ezequiel Bernabeu, Ezequiel Bernabeu, José A. Rodríguez, Shabnum Patel, Maggie Koz...
https://www.sciencedirect.com/science/article/pii/S0301008219301340
Obtaining efficient drug delivery to the brain remains the biggest challenge for the development of therapeutics to treat diseases of the central nervous system. The main obstacle is the blood-brain barrier (BBB), which impedes the entrance of most molecules present in the systemic circulation, especially large molecule drugs and nanomedicines.Author: Kasper Bendix Johnsen, Annette Burkhart, Louiza Bohn Thomsen, Thomas Lars Andresen, Torben Moos
https://www.sciencedirect.com/topics/medicine-and-dentistry/transferrin
Transferrin has several advantages for targeted delivery to cancer cells. Human transferrin is nonimmunogenic; therefore, it can be safely delivered without causing toxicity. Transferrin-conjugated drugs have been shown to prevent cardiotoxicity and drug resistance (Singh, 1999). Transferrin has been used to successfully deliver many cancer drugs.
http://pharmrev.aspetjournals.org/content/54/4/561
Dec 01, 2002 · The coupling of DNA to transferrin via a polycation or liposome serves as a potential alternative to viral vector for gene therapy. Moreover, the OX26 monoclonal antibody against the rat transferrin receptor offers great promise in the delivery of therapeutic agents across the blood-brain barrier to the brain.Author: Zhong Ming Qian, Hongyan Li, Hongzhe Sun, Kwokping Ho
https://www.sciencedirect.com/topics/neuroscience/transferrin
Transferrin has several advantages for targeted delivery to cancer cells. Human transferrin is nonimmunogenic; therefore, it can be safely delivered without causing toxicity. Transferrin-conjugated drugs have been shown to prevent cardiotoxicity and drug resistance (Singh, 1999). Transferrin has been used to successfully deliver many cancer drugs.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4402741/
Transferrin and cell-penetrating peptide dual-functioned liposome for targeted drug delivery to glioma. Address correspondence to: Dr. Kun Yang, Department of Neurosurgery, The Affiliated Hospital of Hainan Medical College, 31, Longhua Road, Haikou City, 570102, China.Author: Chuanyi Zheng, Chunyang Ma, Enqi Bai, Kun Yang, Ruxiang Xu
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