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https://www.diabetesnet.com/about-diabetes/insulin/insulin-delivery/transdermal-insulin-delivery/
Transdermal Insulin Delivery One of the skin’s primary roles is to provide protection against infection and physical damage. This barrier is so effective that it prevents many pharmaceutical compounds from crossing into the bloodstream.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6556146/
Jan 15, 2019 · A transdermal delivery strategy transports insulin across the skin barrier represents a minimally invasive and attractive method for insulin delivery in contrast to painful hypodermic injections [24, 25]. It also has several advantages over oral, pulmonary, and nasal administration techniques.Author: Yuqi Zhang, Yuqi Zhang, Jicheng Yu, Anna R. Kahkoska, Jinqiang Wang, Jinqiang Wang, John B. Buse, Zh...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3152630/
Transdermal delivery of insulin is attractive as a noninvasive method that offers the convenience of a transdermal patch . However, the skin’s barrier properties prevent absorption of useful amounts of insulin.Author: Samantha Andrews, Jeong Woo Lee, Seong-O Choi, Mark R. Prausnitz
https://www.sciencedirect.com/science/article/pii/S0169409X18303090
Jet injection is another needle-free administration for transdermal insulin delivery. Instead of solid syringes, the jet injector applies a high-speed narrow stream containing insulin to create a tiny hole for insulin transport through the skin [[135], [136], [137]].Author: Yuqi Zhang, Yuqi Zhang, Jicheng Yu, Anna R. Kahkoska, Jinqiang Wang, Jinqiang Wang, John B. Buse, Zh...
http://www.diabetesincontrol.com/the-transdermal-insulin-drug-delivery-tdd-system/
The Transdermal Insulin Drug Delivery (TDD) System Dermisonics’ research has centered upon the creation of a unique hardware platform, to make a wearable, lightweight drug delivery system possible. The Transdermal Drug Delivery (TDD) System employs a flexible patch design integral to the new two-part TDD called the Medi-Cap.
https://professional.diabetes.org/abstract/transdermal-delivery-insulin-patients-type-1-diabetes
Transdermal Delivery of Insulin in Patients with Type 1 Diabetes A novel daily transdermal insu A novel daily transdermal insulin patch is being developed to provide basal levels of insulin in patients with type 1 or type 2 diabetes.
https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/transdermal-delivery
Transdermal delivery (Figure 2.5) is an attractive possibility for the delivery of insulin because it offers various advantages. The advantages and disadvantages of transdermal delivery systems …
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