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https://www.sciencedirect.com/science/article/pii/S0168365920300201
Laser is a monochromatic and coherent light with broad applications in surgery and medicine. Laser has also been explored to ablate SC layer to facilitate transdermal drug delivery by taking advantage of its photothermal and photomechanical effects [5,6].Author: Prateek Kakar, Zhuofan Li, Yibo Li, Yan Cao, Xinyuan Chen
https://www.sciencedirect.com/science/article/pii/S0168365901003911
The laser had a greater effect on the permeation of hydrophilic molecules which usually possess low permeability. The laser intensity and its spot size were found to play an important role in controlling transdermal delivery of drugs. Permeation of the hydrophilic drug increased following an increase of laser …Author: Woan Ruoh Lee, Woan Ruoh Lee, Shing Chuan Shen, Shing Chuan Shen, Hsien Hung Lai, Hsien Hung Lai, Ch...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4695828/
Oct 22, 2015 · 2. Transdermal Drug Delivery (TDD) TDD is a painless method of delivering drugs systemically by applying a drug formulation onto intact and healthy skin [2,5]. The drug initially penetrates through the stratum corneum and then passes through the deeper epidermis and dermis without drug accumulation in the dermal layer.Author: Ahlam Zaid Alkilani, Maelíosa T.C. McCrudden, Ryan F. Donnelly
https://www.sciencedirect.com/science/article/pii/S1578219018303664
Absorption of topical products through the epidermis is limited by the skin's barrier function. Numerous techniques and agents such as microneedling, dermabrasion, radiofrequency, and lasers have been used to increase penetration within an approach known as transdermal drug delivery. One of these techniques is laser-assisted drug delivery (LADD),...Author: Douglas Murphy-chutorian, Richard L. Mueller, Stuart D. Harman, Steven A. Daniel, Larry Witham, Robe...
https://www.researchgate.net/publication/255991094_Laser_ablation-enhanced_transdermal_drug_delivery
Laser ablationenhanced transdermal drug delivery using wavelengths of CO2 and Er:YAG lasers at 10,600 nm and 2940 nm have been investigated to heat the skin to …
https://www.frontiersin.org/articles/10.3389/fbioe.2018.00015/full
For thermal ablation-enhanced transdermal drug delivery, higher laser energies with pulse durations less than microsecond are ideal to limit heat transfer to surrounding tissue. Indeed, while the skin surface is extremely hot, the viable epidermis and deeper skin tissue is not, largely eliminating side effects and fast improved safety.Author: Sabine Szunerits, Rabah Boukherroub
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