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https://www.sciencedirect.com/science/article/pii/S0169409X12002724
In situ hydrogel formation makes it more feasible to apply hydrogels for macromolecular drug delivery, tissue barriers, and tissue engineering. A particularly interesting and important polymeric system is hydrogel forming solutions by a simple phase transition (sol–gel transition) in water without any chemical reaction or external stimulation.Author: Byeongmoon Jeong, Sung Wan Kim, You Han Bae
https://www.researchgate.net/publication/232646895_Thermosensitive_Polymeric_Hydrogels_As_Drug_Delivery_Systems
Thermosensitive hydrogels have great potential in various applications, such as drug delivery, cell encapsulation, tissue engineering, and etc. Especially, injectable thermosensitive hydrogels ...
https://www.researchgate.net/publication/51118830_Thermosensitive_hydrogels_for_drug_delivery
Thermosensitive hydrogel-based drug delivery systems have increasingly attracted the attention of the drug delivery community, as the drugs can be readily encapsulated and released by the hydrogels.
https://www.hindawi.com/journals/bmri/2017/3564060/
Thermosensitive hydrogels have increasingly received considerable attention for local drug delivery based on many advantages. However, burst release of drugs is becoming a critical challenge when the hydrogels are employed. Microspheres- (MS-) loaded thermosensitive hydrogels were thus fabricated to address this limitation.Author: Ting-Ting Yang, Yuan-Zheng Cheng, Meng Qin, Yong-Hong Wang, Hong-Li Yu, An-Lin Wang, Wei-Fen Zhang
https://www.sciencedirect.com/science/article/pii/S0032386108000487
Significant progress has been made in improving the properties of hydrogels used for drug delivery and expanding the range of drugs and kinetics which can be achieved using a hydrogel-based delivery vehicle. However, several challenges remain to improve …Author: Todd R. Hoare, Daniel S. Kohane
https://link.springer.com/article/10.1007%2Fs10965-019-1771-z
May 03, 2019 · Hydrogels are unique biomaterials that have demonstrated tremendous potential in sustaining drug release. Significant effort has been made to impart stimuli sensitivity and incorporate hydrophilic molecules in a stable hydrogel network. Although, thermosensitive hydrogels have exhibited promising interventions, formulation of a biodegradable, stable thermosensitive hydrogel for sustained …Author: Pratikkumar Patel, Abhirup Mandal, Vrinda Gote, Dhananjay Pal, Ashim K. Mitra
https://www.ncbi.nlm.nih.gov/pubmed/29096548
Thermosensitive hydrogels a versatile concept adapted to vaginal drug delivery. ... of the vaginal environment and how it impacts the safe and efficient vaginal delivery and also reviewed several thermosensitive hydrogels deemed suitable for vaginal drug delivery by addressing specific characteristics, which are essential to engage the vaginal ...Author: Sebastien Taurin, Aliyah A. Almomen, Tatianna Pollak, Sun Jin Kim, John Maxwell, C. Matthew Peterson...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4158699/
This is the first report successfully incorporating 3 highly hydrophobic drugs in the platform of thermosensitive hydrogels for the IP multi-drug delivery in oncology. Figure 1 Schematic illustration of a sol-gel transition of thermosensitive PLGA- b -PEG- b -PLGA hydrogels carrying paclitaxel, 17 …Author: Hyunah Cho, Glen S. Kwon
https://www.hindawi.com/journals/jnm/2011/389640/
Thermosensitive nanocarriers as the “smart” drug delivery systems have shown tremendous promise in the field of controlled drug delivery due to their special property. Thermosensitive nanocarriers with long circulation properties can accumulate in the pathological sites by enhanced permeability and retention (EPR) effect or attach targeting ligands to the surface of the nanocarriers, and ...Author: Pengyu Shao, Bochu Wang, Yazhou Wang, Jun Li, Yiqiong Zhang
https://pubs.acs.org/doi/abs/10.1021/acsami.5b09112
Localized cancer treatments with combination drugs have recently emerged as crucial approaches for effective inhibition of tumor growth and reoccurrence. In this study, we present a new strategy for the osteosarcoma treatment by localized co-delivery of multiple drugs, including doxorubicin (DOX), cisplatin (CDDP) and methotraxate (MTX), using thermosensitive PLGA–PEG–PLGA hydrogels.Author: Hecheng Ma, Chaoliang He, Yilong Cheng, Zhiming Yang, Junting Zang, Jianguo Liu, Xuesi Chen
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