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https://www.sciencedirect.com/science/article/pii/S0378517310005090
1. Introduction. The transdermal drug delivery system (TDDS) is a promising drug formulation that can not only be easily applied without the aid of medical staff compared to injectable formulations, but also offers several advantages, including the elimination of hepatic first-pass metabolism and severe adverse effects on the gastrointestinal tract of oral dosage forms (Jonathan Hadgraft et al ...Author: Keshu Yan, Hiroaki Todo, Kenji Sugibayashi
https://www.researchgate.net/publication/45148432_Transdermal_drug_delivery_by_in-skin_electroporation_using_a_microneedle_array
Transdermal drug delivery by in-skin electroporation using a microneedle array Article in International Journal of Pharmaceutics 397(1-2):77-83 · September 2010 with 153 Reads How we measure 'reads'
http://libir.josai.ac.jp/il/user_contents/02/G0000284repository/pdf/JOS-j.ijpharm.2010.06.052.pdf
Transdermal drug delivery by in-skin electroporation using a microneedle array Keshu Yan, Hiroaki Todo and Kenji Sugibayashi* Faculty of Pharmaceutical Sciences, Josai University, 1-1 Keyakidai, Sakado, Saitama 350-0295, Japan * Corresponding author: Tel.: +81-49-271-7943 Fax: +81-49-271-8137 E-mail: [email protected]
https://www.ncbi.nlm.nih.gov/pubmed/20619329
Sep 15, 2010 · Transdermal drug delivery by in-skin electroporation using a microneedle array. ... for the delivery of macromolecular drugs to the deep skin tissues, so-called in-skin electroporation (IN-SKIN EP), using a microneedle (MN) electrode array. Fluorescein isothiocyanate (FITC)-dextran (FD-4: average molecular weight, 4.3 kDa) was used as the model ...Author: Keshu Yan, Hiroaki Todo, Kenji Sugibayashi
https://www.sciencedirect.com/science/article/pii/S0927796X16300213
As detailed above, Henry et al. published the first research work using MN for transdermal drug delivery . This work described the use of solid silicon MNs for the delivery of calcein (model drug) using the ‘poke and patch’ approach (see Section 2.2). Since then, this approach have been used extensively employed, using mainly silicon and ...Author: Eneko Larrañeta, Rebecca E.M. Lutton, A. David Woolfson, Ryan F. Donnelly
https://www.researchgate.net/publication/4166158_An_electrically_active_microneedle_array_for_electroporation_of_skin_for_gene_delivery
An electrically active microneedle array for electroporation of skin for gene delivery ... A fully integrated microneedle based transdermal drug delivery system ... An electrically active ...
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