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https://www.sciencedirect.com/science/article/pii/S0168365920300912
To avoid hypoglycemia and improve controllability of insulin delivery, glucose- responsive compounds for fabrication of smart insulin delivery systems stimulate interest of the scientific world . A smart insulin delivery system is always comprised of a glucose-responsive unit and an insulin carrier .Author: Di Shen, Haojie Yu, Li Wang, Amin Khan, Fazal Haq, Xiang Chen, Qiao Huang, Lisong Teng
https://www.nature.com/articles/s41551-019-0508-y
Feb 03, 2020 · Glucose-responsive insulin delivery systems that mimic pancreatic endocrine function could enhance health and improve quality of life for people with type 1 …Author: Jicheng Yu, Jinqiang Wang, Jinqiang Wang, Yuqi Zhang, Guojun Chen, Guojun Chen, Weiwei Mao, Yanqi Ye...
https://advances.sciencemag.org/content/3/11/eaaq0723.full
Nov 01, 2017 · Fig. 1 Structure and principle of the boronate gel–based insulin delivery system. (A) Glucose-dependent equilibria of PBA derivatives.(B) Chemical structure of glucose-responsive gel.Monomers and their polymerized (cross-linked) chemical structures are shown with their optimized molar fraction (l:m:n = 87.5:7.5:5) to yield the glucose sensitivity under physiological conditions (pH …Author: Akira Matsumoto, Miyako Tanaka, Hiroko Matsumoto, Kozue Ochi, Yuki Moro-oka, Hirohito Kuwata, Hirohi...
https://pubs.acs.org/doi/10.1021/acsnano.9b06395
A glucose-responsive closed-loop insulin delivery system mimicking pancreas activity without long-term side effect has the potential to improve diabetic patients' health and quality of life. Here, we developed a novel glucose-responsive insulin delivery device using a …Author: Lisa R. Volpatti, Morgan A. Matranga, Abel B. Cortinas, Derfogail Delcassian, Derfogail Delcassian, ...
https://www.pnas.org/content/112/27/8260
Jul 07, 2015 · An artificial pancreas-like, closed-loop, glucose-responsive insulin delivery system that is able to “secrete” insulin in response to elevated blood glucose would provide a desirable way of regulating glycemia with minimal patient effort and potential improvements in glycemia and quality of …Author: Jicheng Yu, Yuqi Zhang, Yanqi Ye, Rocco DiSanto, Wujin Sun, Davis Ranson, Frances S. Ligler, John B....
https://onlinelibrary.wiley.com/doi/abs/10.1002/adma.201606617
Here the authors report the development of a new glucose‐responsive insulin delivery system based on the potential interaction between the glucose derivative‐modified insulin (Glc‐Insulin) and glucose transporters on erythrocytes (or red blood cells, RBCs) membrane.Author: Chao Wang, Yanqi Ye, Wujin Sun, Jicheng Yu, Jingqiang Wang, David S. Lawrence, John B. Buse, Zhen Gu
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