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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1853346/
Feb 12, 2007 · Transdermal drug delivery is an especially attractive alternative, because it is usually easy to use, ... Delivery from coated microneedles was found to be efficient, where the vast majority of coated drug was deposited in the skin and essentially no residue was found on the skin surface, which suggests high bioavailability. ...Author: Harvinder S. Gill, Mark R. Prausnitz
https://www.sciencedirect.com/science/article/pii/S0169409X03002394
Images of microneedles used for transdermal drug delivery. (a) Solid microneedles (150 μm tall) etched from a silicon wafer were used in the first study to demonstrate microneedles for transdermal delivery. (b) Solid microneedles (1000 μm tall) laser-cut from a stainless steel sheet were used to …Author: Mark R Prausnitz
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588187/
Jun 29, 2015 · Transdermal drug delivery offers a number of advantages including improved patient compliance, sustained release, avoidance of gastric irritation, as well as elimination of pre-systemic first-pass effect. ... Pearton et al. used coated microneedles to delivery plasmid DNA . Optimization of a dip-coating method enabled significant increases in ...Author: Kevin B. Ita
https://www.sciencedirect.com/science/article/pii/S0263876208001573
Schematic of coated microneedles for transdermal drug delivery. L u is the uncoated microneedle length, L is the total microneedle length, h is the epidermis thickness and H is the thickness of the skin after microneedles have been inserted, i.e., the distance between microneedle tip and the …Author: Adam Davidson, Barrak Al-Qallaf, Diganta Bhusan Das
http://drugdelivery.chbe.gatech.edu/Papers/2007/Gill%20J%20Control%20Release%202007.pdf
Coated microneedles for transdermal delivery Harvinder S. Gilla, Mark R. Prausnitza,b,⁎ a Wallace H. Coulter Department of Biomedical Engineering at the Georgia Institute of Technology and Emory University, Atlanta, Georgia, USA b School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, Georgia, USA Received 7 August 2006; accepted 18 October 2006
https://www.researchgate.net/publication/315591197_Fabrication_of_coated_polymer_microneedles_for_transdermal_drug_delivery
These results demonstrated that the coated polymer MN was a safe and effective method for transdermal drug delivery. ... Fabrication of coated polymer microneedles for transdermal drug delivery ...
https://onlinelibrary.wiley.com/doi/full/10.1111/j.2042-7158.2011.01369.x
A limited amount of drug could be coated over the microneedles (only about 1 mg) and extensive optimization was required for uniform coating in this ‘coat and poke’ approach. ... This is the main reason why many workers in the pharmaceutical industry strive for successful development of microneedles as transdermal drug delivery systems.Author: Shital H. Bariya, Mukesh C. Gohel, Tejal A. Mehta, Om Prakash Sharma
https://www.researchgate.net/publication/6631457_Coated_Microneedles_for_Transdermal_Delivery
Coated Microneedles for Transdermal Delivery. ... needle shafts attached to a base substrate and coated with a drug on their surfaces. Coated microneedles are under investigation for drug delivery ...
https://drug-dev.com/recent-developments-in-microneedle-technology-for-transdermal-drug-delivery-vaccination/
Mikolaj Milewski and Amitava Mitra highlight some of the recent advances in the field of microneedle-mediated transdermal drug delivery and vaccination, including summaries of preclinical pharmacokinetic data and a brief overview of clinical studies, encompassing the time period from 2010 to present day.
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