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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2700785/
The first transdermal system for systemic delivery—a three-day patch that delivers scopolamine to treat motion sickness—was approved for use in the United States in 1979. A decade later, nicotine patches became the first transdermal blockbuster, raising the profile of transdermal delivery in medicine and for the public in general ...Author: Mark R Prausnitz, Robert Langer
https://www.sciencedirect.com/topics/nursing-and-health-professions/transdermal-drug-delivery-system
The transdermal drug delivery system is a technique that provides drug absorption via the skin. The system has many advantages over conventional administration routes such as intravenous or oral administration for systemic and local drug delivery with simple administration. It is available outside medical institutions, which decreases the ...
https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/transdermal-delivery
The ideal characteristics of a transdermal delivery system include low molecular weight, lipophilicity, high potency, and reliable patch adhesion. 211 The drug’s solubility in the adhesive, its diffusion coefficient, and its permeability coefficient also play major roles in the time to steady-state release into the skin. 212 Release rates of ...
https://www.researchgate.net/publication/270015915_Transdermal_drug_delivery_system_An_overview
Transdermal drug delivery system (TDDS) is one of the systems lying under the category of controlled drug delivery, in which the aim is to deliver the drug through the skin in a predetermined and ...
http://ijpsr.com/bft-article/transdermal-drug-delivery-system-a-review/?view=fulltext
12.2 Polymer matrix: Polymers are the backbone of transdermal drug delivery system. System for transdermal delivery are fabricated as multi layered polymeric laminates in ehich a drug reservoir or a drug polymer matrix is sandwitched between two polymeric layers, an outer impervious backing layer that prevents the loss of drug through the backing surface and an inner polymeric layer that ...
https://www.fdanews.com/ext/resources/files/2019/11-20-19-TDSdraftguidance.pdf?1574288455
Transdermal delivery systems are designed to deliver an active ingredient (drug substance) 36 across the skin and into systemic circulation, while topical delivery systems are designed to 37 deliver the active ingredient to local tissue.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4695828/
Oct 22, 2015 · The first transdermal patch approved for systemic delivery in 1979 was a patch for the sustained, three days delivery of scopolamine in the treatment of motion sickness [1,34]. Transdermal delivery is currently restricted to approximately 17 drug molecules that are approved by the US Food and Drug Administration (FDA) ( Table 1 ) [ 2 , 4 ].Author: Ahlam Zaid Alkilani, Maelíosa T.C. McCrudden, Ryan F. Donnelly
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