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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3061492/
Parel discussed the history of iontophoresis in medicine and followed by summarizing his experiences since the 1970s using the coulomb-controlled iontophoresis unit for transcorneal and transscleral drug delivery (Parel JM, et al., manuscript in preparation). 46 Iontophoresis is a noninvasive method of propelling charged active compounds (e.g ...Author: Henry F. Edelhauser, Cheryl L. Rowe-Rendleman, Michael R. Robinson, Daniel G. Dawson, Gerald J. Chad...
https://www.sciencedirect.com/science/article/abs/pii/0025556488901125
The dynamic characteristics of a transcorneal drug delivery after dose instillation is simulated by a pharmacokinetic model, which takes into consideration the corneal diffusion, metabolism, binding, aqueous-humor elimination, tear flow dynamics, and tissue distributions.Author: Kakuji Tojo
https://www.researchgate.net/publication/265474596_Transcorneal_drug_delivery_prospects_for_the_use_of_liposomes
the interaction of drugs and ocular surface barriers as well as the prospects for the use of liposomes for transcorneal drug delivery. Key words: cornea, transcorneal barriers, ...
https://www.sciencedirect.com/science/article/pii/S1773224718310360
As transcorneal drug delivery is still a challenge, the scope of the present study was to prepare useful nanosystems able to enhance transcorneal permeation/penetration of drugs.Author: Giulia Di Prima, Flavia Bongiovì, Fabio Salvatore Palumbo, Giovanna Pitarresi, Mariano Licciardi, Ga...
https://www.ncbi.nlm.nih.gov/pubmed/25306734
[Transcorneal drug delivery: prospects for the use of liposomes]. [Article in Russian] Aliautdin RN, Iezhitsa IN, Agarval R. Anatomical and physiological ocular surface barriers are responsible for low bioavailability of topical ophthalmic drugs.Author: Aliautdin Rn, Iezhitsa In, Agarval R
http://drugdelivery.chbe.gatech.edu/Papers/1998/Prausnitz%20J%20Pharm%20Sci%201998.pdf
REVIEW ARTICLE Permeability of Cornea, Sclera, and Conjunctiva: A Literature Analysis for Drug Delivery to the Eye MARK R. PRAUSNITZ* AND JEREMY S. NOONAN Contribution from Schools of Chemical Engineering and Biomedical Engineering, Georgia Institute of …
https://link.springer.com/article/10.1007%2Fs13346-018-0504-x
Mar 05, 2018 · Most medications targeting optic neuropathies are administered as eye drops. However, their corneal penetration efficiencies are typically < 5%. There is a clear, unmet need for novel transcorneal drug delivery vehicles. To this end, we have developed a stimulus-responsive, in situ-forming, nanoparticle-laden hydrogel for controlled release of poorly bioavailable drugs into the …Author: Maryam Kabiri, Syed H. Kamal, Sandip V. Pawar, Protiva R. Roy, Maziar Derakhshandeh, Maziar Derakhsh...
https://www.tandfonline.com/doi/abs/10.1080/17425247.2017.1266334
Sep 25, 2015 · ABSTRACTIntroduction: Iontophoresis is an active non-invasive drug delivery technique that can increase the transport of charged and neutral molecules into and across biological membranes. Most research to-date has focused on (per)cutaneous iontophoretic drug delivery. However, recent studies illustrate its potential for drug delivery to the eye: corneal iontophoresis may enable targeted ...Author: Taís Gratieri, Verena Santer, Yogeshvar N. Kalia
https://drum.lib.umd.edu/bitstream/handle/1903/3609/umi-umd-3457.pdf;sequence=1
The main goal of ocular drug delivery is controlled release of therapeutic concentrations to specific tissues while avoiding systemic spread of the formulation. However, the eye presents several anatomic and physiologic barriers that pose a major challenge for targeted drug delivery, especially to …
https://www.mattek.com/reference-library/transcorneal-iontophoresis-for-delivery-of-ciprofloxacin-hydrochloride/
Abstract. Purpose: To investigate the feasibility of utilizing iontophoresis for delivery of ciprofloxacin hydrochloride to the anterior chamber of the eye and to carry out systematic studies to investigate the effect of electrical protocol on the transcorneal drug delivery.
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