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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2865784/
The results indicate that it is possible to deliver central nervous system drugs through the brain targeted transcranial route when applied on the scalp as oil solubilized dosage form. Systemic side effects of many common drugs could be overcome by the administration through the transcranial route since the drug targets the brain.
https://www.researchgate.net/publication/261000815_Transcranial_Drug_Delivery_for_Neurological_Disorders
Request PDF Transcranial Drug Delivery for Neurological Disorders Traumatic brain injury (TBI) leads to focal and diffusible injuries, including neuronal cell death and loss of brain functions.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3425060/
More over it is a non invasive method of determining the effects of diazepam on the nerve tissue of the brain. As the transcranial delivery of diazepam is targeted to the brain it is unlikely for the drug to achieve any possible detectable concentration in the systemic blood circulation by the routine methods of analysis and therefore blood ...
https://www.sciencedirect.com/science/article/pii/S1471489206001172
Transcranial brain drug delivery. Attempts to bypass the BBB involve the intracerebroventricular (ICV) infusion of drug, the intracerebral (IC) implantation of drug and the convection-enhanced diffusion (CED) of drug. ICV drug administration delivers drug to the ependymal surface of the brain but not deep into brain parenchyma.Author: William M Pardridge
http://www.ijpsonline.com/articles/brain-targeted-transcranial-route-of-drug-delivery-of-diazepam.html
Jul 31, 2004 · There is a good prospect in adopting the transcranial route in veterinary practice as well. Development of subscalpal injections is another possibility. The proposed brain targeted transcranial route of drug delivery could be viewed as a parallel drug delivery system to that of metered dose inhalers in diseases of the respiratory system.Author: W Pathirana, S Himani Kariyawasam, Hemamali Tibbotumunuwa, K Perera
http://europepmc.org/articles/PMC4078733
There is an increasing interest in the use of ultrasound to enhance drug delivery to the brain and central nervous system. Disorders of the brain and CNS historically have had poor response to drug therapy due to the presence of the Blood-Brain barrier (BBB).
http://med.stanford.edu/content/dam/sm/scitprogram/documents/seminar_pdfs/2018/Aryal_SCIT_082918.pdf
Brain Drug Delivery 7/21 Aryal et al. Advanced Drug Delivery Review; 2014 Limitations m 1. Blood Brain Barrier (BBB) Tight junction between two endothelial cells in the cerebral microvasculature Good for normal brain to maintain brain function by influx of nutrients & the efflux of wastes and toxins
https://www.ijpsonline.com/articles/transcranial-route-of-brain-targeted-delivery-of-methadone-in-oil.pdf
associated with the brain show that a drug could be transcranially delivered and targeted to the brain through the scalp. The present study was to investigate by measuring the antinociceptive effect on rats whether the opioid analgesic methadone could be delivered and targeted to the brain by transcranial delivery route. A non aqueousAuthor: W Pathirana, P Abhayawardhana, H Kariyawasam, WD Ratnasooriya
https://www.sciencedaily.com/releases/2014/08/140804065940.htm
Aug 04, 2014 · Active research is taking place in the field of transcranial ultrasound therapy, which in the future can potentially be applied to the treatment of brain tumours and targeted drug delivery.
https://www.researchgate.net/publication/44618625_Transcranial_Route_of_Brain_Targeted_Delivery_of_Methadone_in_Oil
PDF The unique anatomical arrangement of blood vessels and sinuses in the human skull and the brain, the prevalence of a high density of skin... Find, read and cite all the research you need ...
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