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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2685069/
Gene trapping is rapid, cost-effective, and produces a large variety of insertional mutations throughout genome . Transgenic mouse models can also be used to evaluate tissue-specific promoters in vivo. Note that promoter methylation often is involved in the regulation of tissue-specific promoters .
https://www.nature.com/articles/s41565-020-0669-6?error=cookies_not_supported&code=77395623-c20b-4a56-a39c-72d2c8d16cc2
The addition of selective organ targeting molecules to nanoparticles allows the specific targeting of extrahepatic tissues, enabling gene editing of distinct cell populations outside the liver.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2557000/
Sep 23, 2008 · In order to achieve thorough perfusion in one specific tissue but not throughout the entire body, greater control may be required. In addition to the physical delivery route, another way to confine expression is by choosing a gene delivery vehicle with a high natural tropism for the tissue of interest.Author: Christina A Pacak, Yoshihisa Sakai, Bijoy D Thattaliyath, Cathryn S Mah, Barry J Byrne
https://www.sciencedirect.com/science/article/pii/S0142961209010874
The same particles coated at a higher 20:1 w/w form small 200 nm particles in the presence of serum that can facilitate specific gene delivery to the spleen and bone marrow. Thus, variations in nanoparticle peptide coating density can alter the tissue-specificity of gene delivery in vivo.Author: Todd J. Harris, Jordan J. Green, Peter W. Fung, Robert Langer, Daniel G. Anderson, Sangeeta N. Bhati...
https://gvt-journal.biomedcentral.com/articles/10.1186/1479-0556-6-13
Sep 23, 2008 · In order to achieve thorough perfusion in one specific tissue but not throughout the entire body, greater control may be required. In addition to the physical delivery route, another way to confine expression is by choosing a gene delivery vehicle with a high natural tropism for the tissue of interest.Author: Christina A Pacak, Yoshihisa Sakai, Bijoy D Thattaliyath, Cathryn S Mah, Barry J Byrne
https://www.liebertpub.com/doi/10.1089/hum.2019.127
Dec 16, 2019 · There are many kidney diseases that might be addressed by gene therapy. However, gene delivery to kidney cells is inefficient. This is due, in part, to the fact that the kidney excludes molecules above 50 kDa and that most gene delivery vectors are megaDaltons in mass.Author: Jeffrey D. Rubin, Tien V. Nguyen, Kari L. Allen, Katayoun Ayasoufi, Michael A. Barry
https://www.researchgate.net/publication/5380249_Evaluation_of_Promoters_for_Use_in_Tissue-Specific_Gene_Delivery
As for the targeting of specific cells in gene therapy, tissue-specific promoters 41 in the vector bearing TAP-1 or tissue-specific viruses 42 can be used to transfer the TAP-1 based gene into the ...
https://www.nature.com/articles/gt2010138
Oct 21, 2010 · Most efforts to obtain tissue-specific or physiological transgene expression have focused on targeting transcription by developing gene delivery vectors harboring specific promoters.Author: M G Toscano, Z Romero, P Muñoz, M Cobo, K Benabdellah, F Martin
https://plantae.org/protein-delivery-address-codes-are-part-of-the-circuitry-adjusting-tissue-specific-plastid-proteomes/
Mar 17, 2020 · This functions as the address label to direct the delivery of plastid proteins from the cytosol into plastids. Question: In addition to tissue-specific gene expression, is the plastid protein import process also regulated in a tissue-specific manner, ...
https://academic.oup.com/cardiovascres/article/35/3/560/376190
Sep 01, 1997 · A cardiac specific gene expression may be achieved by transgene expression under the control of a specific promoter element. The best characterized promoters for a tissue-specific expression in embryonic and adult ventricular myocardium derive from the myosin light chain-2 (mlc-2v) and the alpha-myosin heavy chain (α-mhc) genes.Author: Wolfgang-M Franz, Thomas Rothmann, Norbert Frey, Hugo A Katus
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