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https://pubs.rsc.org/en/content/articlelanding/2013/mb/c2mb25258a#!
Tissue specific delivery of estrone-conjugated siRNAs - Molecular BioSystems (RSC Publishing) An estrone phosphoramidite, synthesized in a single step, was directly incorporated at the 5′ ends of small interfering RNAs (siRNAs).
https://www.researchgate.net/publication/232087214_Tissue_specific_delivery_of_estrone-conjugated_siRNAs
Tissue specific delivery of estrone-conjugated siRNAs. An estrone phosphoramidite, synthesized in a single step, was directly incorporated at the 5' ends of small interfering RNAs (siRNAs). The resulting estrone-conjugated siRNAs readily pass through cellular membranes and down-regulate the target protein, and show specific distributions in vivo.
http://www.rsc.org/suppdata/mb/c2/c2mb25258a/c2mb25258a.pdf
Supporting Information Tissue Specific Delivery of Estrone-Conjugated siRNAs Eun-Kyoung Bang,a Eun Mi Jeon,a Wanil Kim,b Kyung-Ha Lee,b Kyong-Tai Kim,*b and Byeang Hyean Kim*a aDepartment of Chemistry, BK School of Molecular Science, Pohang University …
https://pubs.acs.org/doi/10.1021/bc800278e
Nov 17, 2008 · To efficiently deliver siRNAs to the target cells and tissues, many different siRNA bioconjugates were synthesized and characterized, and their gene silencing efficiencies were tested in vitro and in vivo. In this review, recent developments of siRNA bioconjugates are summarized.Author: Ji Hoon Jeong, Hyejung Mok, Yu-Kyoung Oh, Tae Gwan Park
https://pubs.acs.org/doi/10.1021/cr0502448
Sep 13, 2006 · Tissue specific delivery of estrone-conjugated siRNAs. Mol. ... Tissue specific delivery of estrone-conjugated siRNAs. Molecular BioSystems 2013, DOI: 10.1039/c2mb25258a. Meng Su, Jie Wang, XinJing Tang. Photocaging Strategy for Functionalisation of Oligonucleotides and Its Applications for Oligonucleotide Labelling and Cyclisation.Author: Natarajan Venkatesan, Byeang Hyean Kim
https://www.nature.com/articles/nprot.2012.131
Nov 15, 2012 · The use of small interfering RNAs (siRNAs) to induce gene silencing has opened a new avenue in drug discovery. However, their therapeutic potential is hampered by inadequate tissue-specific delivery. Exosomes are promising tools for drug delivery across different biological barriers.Author: Samir El-Andaloussi, Samir El-Andaloussi, Yi Lee, Samira Lakhal-Littleton, Jinghuan Li, Yiqi Seow, C...
https://academic.oup.com/nar/article/47/3/1082/5245439
Dec 14, 2018 · The GalNAc moiety drives specific delivery to and activity in hepatocytes . Here we show that lipid conjugates support much broader delivery of siRNAs and enable functional silencing in many tissues, including liver, kidney, lung, heart, muscle, spleen, fat and adrenal glands.Author: Annabelle Biscans, Andrew H. Coles, Reka A. Haraszti, Dimas Echeverria, Matthew R. Hassler, Maire F....
http://www.nature.com/articles/nbt1101
May 22, 2005 · Delivery of small interfering RNAs (siRNAs) into cells is a key obstacle to their therapeutic application. We designed a protamine-antibody fusion protein to …Author: Erwei Song, Pengcheng Zhu, Sang Kyung Lee, Dipanjan Chowdhury, Steven Kussman, Derek M Dykxhoorn, Yi...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2727154/
The challenge of cell- or tissue-specific delivery of siRNAs is also crucial when investigating the utility of RNAi-based therapies for a given disease; various strategies for nonviral and viral delivery of RNAi triggers have shown to be effective in their respective disease models.Author: Daniel H. Kim, John J. Rossi
https://stm.sciencemag.org/content/4/130/130ra48.full
Apr 18, 2012 · However, the most important attribute of F5-P–complexed siRNAs is their cell-specific delivery, which leads to concentration in the target tumor and avoidance of distribution to irrelevant normal tissues . Specific delivery into the intended target cell will likely reduce the dose required for antitumor activity as well as limit toxicity.Author: Yan-dan Yao, Tian-meng Sun, Song-yin Huang, Shuang Dou, Ling Lin, Jia-ning Chen, Jian-bin Ruan, Chen...
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