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https://www.sciencedirect.com/science/article/pii/S0168365999000437
Abstract. This paper describes some successful examples of a tissue selective drug delivery by utilizing specialized transporter(s) expressed in the targeted tissue cells. These are as follows: (1) oral delivery via H + /oligopeptide transporter, rat or human Pept1, in the intestine for β-lactam antibiotics and a newly synthesized dipeptide,...Author: Akira Tsuji
https://www.cell.com/trends/pharmacological-sciences/pdf/S0165-6147(12)00020-X.pdf
to selective drug delivery One of the key challenges in medicine is the creation of therapeutic agents that act only where needed. By specifi-cally targeting diseased tissues, drugs could have im-proved efficacy while displaying limited adverse off-target effects against normal tissue [1]. Targeted delivery …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3169185/
Selective BBB transduction for drug delivery that targets the diseased tissue will improve delivery efficiency and reduce adverse effect, and potentially can be …Author: Shimin Liu, Steven R. Levine, H. Richard Winn
https://www.sciencedirect.com/science/article/pii/S016561471200020X
Introduction to selective drug delivery One of the key challenges in medicine is the creation of therapeutic agents that act only where needed. By specifically targeting diseased tissues, drugs could have improved efficacy while displaying limited adverse off-target effects against normal tissue.Author: Nina Svensen, Jeffrey G.A. Walton, Mark Bradley
https://www.nature.com/articles/s41565-020-0669-6?error=cookies_not_supported&code=77395623-c20b-4a56-a39c-72d2c8d16cc2
Drug Discov. 13, 759–780 (2014 ... P. S. et al. Ionizable amino-polyesters synthesized via ring opening polymerization of tertiary amino-alcohols for tissue selective mRNA delivery. Adv. ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2896002/
Mar 15, 2010 · Nanoliposomes have been used as a carrier for CNS drug delivery and can be tissue selective. Selective delivery of a metabolic suppressor to a specific brain region makes it possible to reach a desired regional drug concentration with minimized drug-related systemic adverse effects (CNS depression, hypotension, etc.), therefore, having its application in acute stroke treatments.Author: Shimin Liu, Steven R. Levine, H. Richard Winn
https://www.nature.com/articles/s41467-019-12848-5
Oct 24, 2019 · Achieving the activation of drugs within cellular systems may provide targeted therapies. Here we construct a tumour-selective cascade activatable self …Author: Hong Wei An, Hong Wei An, Li Li Li, Yi Wang, Yi Wang, Ziqi Wang, Dayong Hou, Yao Xin Lin, Yao Xin Li...
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