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https://www.sciencedirect.com/science/article/pii/S0142961209010874
Here, we develop nanoparticle coatings that direct tissue-specific delivery of polymeric gene vehicles in vivo.In particular, we show that specific tissue delivery can be enhanced by tuning the biophysical properties of coated nanoparticles.Author: Todd J. Harris, Jordan J. Green, Peter W. Fung, Robert Langer, Daniel G. Anderson, Sangeeta N. Bhati...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2796451/
Here, we develop nanoparticle coatings that direct tissue-specific delivery of polymeric gene vehicles in vivo.In particular, we show that specific tissue delivery can be enhanced by tuning the biophysical properties of coated nanoparticles.Author: Todd J. Harris, Jordan J. Green, Peter W. Fung, Robert Langer, Daniel G. Anderson, Sangeeta N. Bhati...
https://www.researchgate.net/publication/38029913_Tissue-Specific_Gene_Delivery_via_Nanoparticle_Coating
Download Citation Tissue-Specific Gene Delivery via Nanoparticle Coating The use of biomaterials for gene delivery can potentially avoid many of the safety concerns with viral gene delivery.
https://lmrt.mit.edu/sites/default/files/Harris_Biomat_2010.pdf
Nanoparticle Targeting Gene delivery Polymer Peptide Self-assembly abstract The use of biomaterials for gene delivery can potentially avoid many of the safety concerns with viral gene delivery. However, the efficacy of polymeric gene delivery methods is low, particularly in vivo. One
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.657.9405
The same particles coated at a higher 20:1 w/w form small 200 nm particles in the presence of serum that can facilitate specific gene delivery to the spleen and bone marrow. Thus, variations in nanoparticle peptide coating density can alter the tissue-specificity of gene delivery in vivo. 1.
http://dspace.mit.edu/openaccess-disseminate/1721.1/75302
sized particles in the presence of serum that can facilitate specific gene delivery to the liver. The same particles coated at a higher 20:1 w/w form small 200 nm particles in the presence of serum that can facilitate specific gene delivery to the spleen and bone marrow. Thus, variations in nanoparticle peptide coating density can alter the ...
https://www.semanticscholar.org/paper/Tissue-specific-gene-delivery-via-nanoparticle-Harris-Green/6f926f0744bb53883c8705f2db07e9e9228c56bf
The use of biomaterials for gene delivery can potentially avoid many of the safety concerns with viral gene delivery. However, the efficacy of polymeric gene delivery methods is low, particularly in vivo. One significant concern is that the interior and exterior composition of polymeric gene delivery nanoparticles are often coupled, with a single polymer backbone governing all functions from ...
https://www.deepdyve.com/lp/elsevier/tissue-specific-gene-delivery-via-nanoparticle-coating-zmhhi7C5SO
Feb 01, 2010 · Read "Tissue-specific gene delivery via nanoparticle coating, Biomaterials" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
https://core.ac.uk/display/9591929
Tissue-Specific Gene Delivery via Nanoparticle Coating By Todd J. Harris, Jordan J. Green, Peter W. Fung, Robert Langer, Daniel G. Anderson and Sangeeta N. Bhatia Download PDF (609 KB)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4046008/
May 21, 2014 · Nanoparticles in gene delivery. In the field of nanomedicine, nanotechnology methods focus on formulating therapeutic biocompatible agents such as nanoparticles, nanocapsules, micellar systems, and conjugates [22,23].Nanoparticles are solid and spherical structures ranging to around 100 nm in size and prepared from natural or synthetic polymers [].Author: Solmaz Maleki Dizaj, Samira Jafari, Ahmad Yari Khosroushahi
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